The human papillomavirus (HPV) infection is a sexually transmitted disease that is easily recurring and difficult to treat in some patients, and because it occurs in the genital area, it is an unspeakable fear of transmission to family members and causes great psychological stress to patients. The newborn is born with a vaginal contamination of the skin and mucous membranes with warts, which can lead to papillomatosis and condyloma. Treatment of condyloma acuminata during pregnancy is often a dilemma that involves both maternal and fetal considerations, and therefore requires balancing various efficacy and adverse effects to choose the best treatment option. ALA-PDT is an important method for the treatment of warts. The warts can selectively absorb 5-ALA to achieve drug concentration in the lesion, through the heme synthesis pathway, into the photosensitive substance pPIX, after a certain wavelength of light excitation, resulting in photodynamic effect, because the concentration of the drug in the lesion is higher than normal tissue, so it can selectively destroy the warts, while the normal tissue can be maximized. The treatment of condyloma acuminatum is based on the use of light. The photosensitizer 5-ALA used in the treatment of warts is a component of the heme synthesis pathway, which is widely available in the human body and can be degraded quickly in the body, theoretically without affecting the fetus. The patient’s warts were characterized by large, fast-growing warts. In this case, after six photodynamic treatments, the lesions were completely regressed.