The HPV16 positive infection only indicates a higher chance of malignancy, but does not directly affect the survival time of the patient, which depends on the degree of infection and the resistance of the patient’s own body. HPV has a high possibility of self-healing, and when the patient’s body resistance is strong, the body’s own cellular or humoral immunity can clear the virus. At this time, the survival time of patients is the same as normal people, as long as they can actively receive treatment, they will not develop into cervical cancer. However, if the patient does not actively receive treatment, the serious condition may lead to cervical cancer. For those who have been infected with HPV16 for more than 1 year or even longer, the body has no way to clear the virus by itself or has immunodeficiency disease and malignant lesions, such as cervical cancer, need to be treated actively to avoid malignant lesions affecting patients’ life expectancy and quality of life. When patients have infections, they should maintain a good psychological state and promptly undergo treatment under the guidance of professional doctors to achieve early diagnosis and early treatment. In life, we should pay attention to sufficient sleep, avoid staying up late, moderate physical exercise to increase the immunity of the body. When having sex, pay attention to protection and avoid cross-infection.