Ms. Wang is a bit sullen today, she just received this year’s physical examination report, the physical examination report has some problems, cervical smear (TCT): can not be clear significance of atypical squamous cells, HPV test is recommended. She remembered that a good sister in the unit last year, just 40 years old, also had problems with TCT and went to the hospital to find out that she had cervical cancer, surgery and chemotherapy, Ms. Wang could not help but feel a lot of emotions. When she arrived at the hospital, her doctor suggested that she undergo an HPV test, which showed that she was positive for HPV16. The doctor also performed a colposcopy, which showed low-grade intraepithelial lesions. Ms. Wang couldn’t help but have questions: What is HPV? I’m quite hygienic, why would I have this virus? Will I get cervical cancer? 1. What is HPV: HPV is short for human papillomavirus, which only invades humans. There are more than 130 types of HPV identified, about 35 types can infect women’s reproductive tract and about 20 types are associated with tumors. The different HPV types are classified into low-risk and high-risk types according to their risk of tumor development. Low-risk HPV types include HPV6, 11, 42, 43 and 44, which often cause benign lesions such as external genital warts, including low-grade cervical intraepithelial lesions (CIN I), while high-risk HPV types include HPV16, 18, 31, 33, 35, 39, 45, 51 and 52, which are associated with the occurrence of cervical cancer and high-grade cervical intraepithelial lesions (CIN II/III). HPV can be detected in 99% of cervical cancer tissues, and it can be said that HPV is the main culprit of cervical cancer. HPV is highly infectious and can be transmitted to others without obvious symptoms. In addition, close contact, skin abrasions, infants through the infected birth canal, self-inoculation (infection to other parts of the body through scratching) and contaminant transmission are also relatively common routes of transmission. Risk factors for HPV infection include: multiple sexual partners; early sexual activity (before the age of 16); smoking; other sexually transmitted infections; and decreased body resistance due to clinical treatment, AIDS and other causes of immune system deficiency. 3, the infection of HPV virus clinical performance: HPV virus infection incubation period when there are no symptoms, the symptoms appear when the infection is estimated to have 3 months or years. Most anal genital warts have no obvious symptoms, but patients have more anal itching, burning and other symptoms. 4, the relationship between HPV infection and cervical cancer: Since most of the cervical cancer occurrence is related to human papillomavirus transmission, screening for cervical cancer is important. It allows for early detection and treatment of tumors before they spread 5. When to check for HPV: If a cervical thin-layer liquid-based cytology (i.e., TCT) suggests atypical squamous cells of undetermined significance (called ASCUS) or a higher degree of lesion, then HPV testing is indicated. If the HPV test is negative, you can rest assured that the TCT will be repeated in six months. If the HPV test is positive, further tests, colposcopy and biopsy will be needed. 6.Does HPV infection lead to cervical cancer? The chance of developing cervical cancer in people infected with HPV is 0.2%. There is no specific medicine to remove this virus infection, and it can only be cured by improving the body’s immunity and producing antibodies to remove the virus. It usually takes 10 to 15 years to develop cervical cancer after infection with the virus.