Elevated protein in urine test is considered to be proteinuria, caused by protein filtration from the glomerulus, which can be caused by both physiological and pathological factors. 1, physiological proteinuria, most of them are caused by excessive exercise, fatigue, mental tension and hemodynamic changes, increased permeability of glomerular capillaries, which is relatively mild and can be slowly relieved after a period of rest. Avoid strenuous exercise and mental tension can be properly avoided. 2. Pathological proteinuria is mainly caused by glomerular diseases, tubular diseases and tissue destruction. (1) Glomerular proteinuria, caused by impaired glomerular filtration barrier function, such as diabetes, systemic lupus erythematosus, hypertension, etc. (2) tubular proteinuria, such as pyelonephritis, heavy metal poisoning, interstitial nephritis, and post-transplantation kidney. (3) Pseudoproteinuria, such as cystitis, urethral bleeding, due to the presence of blood in the urine, which leads to a positive qualitative protein result in the test. For elevated urine protein must be paid great attention to, most pathological causes are caused by abnormal kidney function, need to actively go to nephrology for further treatment.