Infertility is a common disease in women, and although the outcome is simply the inability to have children, its etiology is quite complex and may have both organic lesions and functional disorders, as well as psychological causes. In a significant proportion of patients, the emphasis is on organic lesions, the disregard is on functional disorders, and the neglect is on psychological disorders. In fact, psychological disorders can also lead to infertility and are also diseases, which also require careful treatment. It is particularly important to emphasize that psychological disorders are more painful, more troublesome and more in need of early treatment for patients. Clinical investigations also show that psychological depression is significantly and positively correlated with infertility, and the influence of psychological factors on infertility has been recognized as one of the infertility factors. According to relevant reports, it is confirmed that the psychological disorders of female infertility are related to factors such as their age, occupation, age of marriage, years of infertility, attitude toward infertility, sexual life satisfaction and education level. The psychological disorders of female infertility patients are mainly reflected in low self-esteem, restlessness, nervousness, reduced socialization, lack of interest in life, restlessness and anger, and reluctance or avoidance to talk with others about fertility, which is especially prominent among infertility patients with low literacy level in rural areas. Of course, this is related to the fact that rural women are deeply influenced by traditional ideology, and they think more about their future life and worry about losing their livelihood security in the future; secondly, it is also related to their own coping ability, ideology and self-regulation. Long-term infertility in women, especially after multiple treatments without effect, often leads to interpersonal sensitivity, anxiety, depression, paranoia, with the prolongation of marriage and age, the psychological pressure is even heavier, and some even have a sense of loss of “no one to succeed”, mental stress is further aggravated, and increasingly lack of confidence in the cure. For patients with psychological disorders of infertility, the main treatment should be psychological. Psychological treatment is multi-faceted, and it depends on the doctor, as well as on the family and oneself. A lot of clinical data prove that excessive mental tension and psychological disorders often lead to endocrine dysfunction and ovulation disorders, creating a situation where the more you want to get pregnant, the harder it is to get pregnant. It is important for patients and their families to understand this truth. In the process of treatment, the role of family members, especially the husband, should not be neglected. For infertility patients, we should respect them, care for them, and be considerate of them. It is not advisable to discuss topics such as infertility, and family members should not intentionally or unintentionally complain, reprimand, or sarcasm, but need to enlighten, encourage, and help, which will not only help patients recover, but also contribute to family harmony and social stability. At the same time, the patients themselves should also improve their “immunity”, to maintain their mental health, reduce doubts, worries, self-blame, low self-esteem, not to blame God, not to avoid the disease, not to take the bull by the horns. To do this, the first thing is to improve awareness, and the improvement of awareness requires basic medical knowledge. Clinical observation suggests that the incidence of psychological disorders among cadres and scientists with higher education level, rich medical knowledge and strong self-regulation ability is much lower than that of patients with low education level, poor medical knowledge and poor self-regulation ability. Reducing or alleviating the psychological disorders of infertility patients can not only improve the natural conception rate, but also improve the quality of life of patients, which is indeed an issue worthy of great attention by the whole society.