Metabolic abnormalities are more common in patients with depressive disorders. However, the relationship between gout and depression is unclear. Researchers explored the relationship between gout, anti-gout medications and the risk of developing depressive disorders. For this cohort study, researchers recruited 34,050 gout patients from the National Health Insurance Research Database as the gout group and 68,100 (gout-free) controls to collect data from the sample. The primary endpoint of the study was the diagnosis of depression during follow-up. All subjects were followed up until the diagnosis of depression, or withdrawal from the study, or the end of the study. A chi-square test was applied to analyze categorical variables and a t-test to analyze continuous variables to determine differences between demographic and clinical information between the two groups. The Cox proportional risk model was applied to study the risk of developing depressive disorders in gout patients. Patients with gout had an increased risk of depressive disorders compared to control patients. Female patients, patients with hypertension, stroke and coronary artery disease had an increased risk of depressive disorders with age. The application of NSAIDs and corticosteroids was associated with a decreased risk of depression. Patients with gout had a decreased risk of depression after anti-gout treatment compared to non-gout patients.