Renal bone disease can be divided into two categories: generalized renal bone disease and narrow renal bone disease. The broad sense of “renal bone disease” refers to all bone diseases related to the kidney or bone diseases with kidney-related causes, such as chondrodysplasia associated with renal tubular acidosis and bone diseases occurring in nephrotic syndrome. Narrowly defined “renal bone disease”, also known as renal osteodystrophy, refers to metabolic bone disease that occurs in chronic renal insufficiency, and can be considered an important complication of chronic renal insufficiency, which can be accompanied by multiple systemic lesions in severe cases. It can be subdivided into high-transport, low-transport and mixed types according to the kinetic changes of bone tissue trans-V. Since the development of dialysis treatment in the 1960s, with the increase of dialysis population in China and the increase of life expectancy of dialysis patients brought by the progress of dialysis technology, the incidence of renal bone disease has been increasing, and the treatment effect is not ideal, which seriously affects the quality of life of patients.