Pediatric constipation is more common and can occur from birth to the teenage years. However, the majority of constipation is functional, without any obvious organic pathology, and the etiological mechanism is not completely clear, but most of them will improve after a few months or years. In some cases, the constipation is transient and improves on its own after a period of dietary modification. However, there are children with functional constipation that is stubborn and very difficult to treat. Parents must have the right understanding and strive for early treatment. In persistent constipation, dietary modification, increasing water intake, stopping or reducing formula feeding, changing formula, behavioral interventions (encouragement, training defecation habits, eliminating fears, etc.), increasing dietary fiber, etc. have no significant effect. About 50% of children gradually improve within 1 year, 25% within 2 years, and 25% take many years to improve. During this period, parents need to understand correctly, not to be impatient, not to rush, and not to sit back and ignore, not to reprimand and blame the child. The most important thing is to rely on safe, mild, non-absorbable laxative drugs to maintain the treatment for a long time and wait for the child’s gastrointestinal function to gradually improve before slowly stopping the medication. Many parents repeatedly stop the medication midway, constipation repeatedly recur, which is not conducive to the continuity and effectiveness of constipation treatment. Children often have a fear of stool because of the severe pain of constipation, so they will deliberately suppress the desire to defecate and delay defecation as much as possible, so constipation gradually worsens, leading to a vicious circle. Therefore, early treatment is needed. Long-term constipation leads to a variety of adverse consequences: affect the physical and mental development of the affected child, the daily fear of psychological stimulation causes immeasurable psychological stress, which in turn affects the plant nervous function, and further harm the normal physiological function of the gastrointestinal tract; mental stress will also affect intellectual development; rectal anal mucosa is dry and hard stool cuts, lacerations, resulting in local chronic inflammation, further affecting its function ; long-term constipation will lead to less and less rectal tension, induction is getting worse, rectal volume is getting bigger and bigger, which also leads to more and more stool accumulation, getting thicker and harder to excrete; constipation will affect toxin excretion, so the body toxins will increase, especially heavy metals; long-term constipation will cause intestinal metabolic disorders; but through effective treatment, this adverse consequence can be prevented or greatly reduced, especially prevent physical and psychological damage to children. There are very many drugs and methods for adult constipation, but research on pediatric constipation has been lagging behind, especially in pharmacological treatment. The reasons for this are many, one is that most parents do not want to take their children as experiments; second is that children can not actively respond to the problem is not easy to cooperate with research; third is that drug developers do not want to spend a lot of effort to make a small fortune. But in the past decade, the United States and other developed countries have done a large number of clinical trials on children’s constipation, so that people have a more scientific understanding of the problem of children’s constipation, in the treatment of a more scientific norms, overturned some empirical methods and traditional understanding. 1, stimulating laxatives are generally used sparingly or not used, such as senna, magnesium sulfate, phenolphthalein tablets, fruit guide tablets, rhubarb tablets, etc.; 2, anal plug preparations such as open plug and enema can only be used temporarily to save the emergency, not as a routine use, not long-term continuous use, because long-term use will cause dependence; 3, behavioral interventions (such as encouragement, toilet training, diet modification, increase exercise, etc.) only for a small number of children Effective, but for most children, can only play a helpful role, can not play a therapeutic role, must be combined with drug therapy; 4, basic drug therapy, the current study that there are two safer drugs, polyethylene glycol 4000 (polyethylene glycol) (Note: domestic Shu Taiqing, divided into A, B package, children can only eat A package; imports seem to have “(Note: the import of lactulose) (Note: the import of Du secret gram), they belong to the osmotic laxative, that is, through the water-absorbing properties of the drug itself, increase the water content of the intestinal contents to keep the stool moist. These two drugs are characterized by their own non-toxicity, and basically not absorbed by the body, and can not be decomposed, oral elimination directly through the intestinal tract (lactulose in the intestinal tract can be metabolized by intestinal probiotics), the intestinal tract itself also has no stimulating effect, so it can be safely taken for a long time. Through a large number of clinical trials and follow-up studies, these two drugs have not been found to have any adverse effects on growth and development, nutrient absorption, toxicity tests, blood index analysis, etc. However, polyethylene glycol 4000 has not been included in the instructions for children with constipation, but it is already being used in children in overseas clinics. Dulcolax is currently for children constipation has been written into the instructions, and pregnant women can also use, so it should be safer. 5, drug treatment should be adhered to a certain period of time, until the child to establish normal bowel function. The time may be 3 months, 6 months, 1 year or several years. After a certain period of time, you can try to reduce the dosage and observe whether you can have normal bowel movement, if you are still constipated, you need to continue the medication. 6, the dose of medication: everyone is not necessarily the same, because these two drugs do not have a “ceiling effect”, that is, no dose limit, so you can safely increase the dose of drugs, you can adjust the medication according to your personal situation, the standard is “to keep the stool moist, fluent, no effort to stool, no pain, and The standard is “to keep the stool moist and loose, without effort and pain, but not too thin”. The medication can be administered once a day or twice a day. 7.Medication can effectively prevent psychological problems and physical injuries caused by long-term constipation, and prevent a series of complications such as hemorrhoids, anal fissures, anal fistulas, perianal abscesses, enteritis, plant nerve disorders, metabolic disorders, and toxin excretion disorders. After effectively relieving constipation, stool becomes a normal physiological need and even a joyful enjoyment, rather than a mental and physical burden, in which case the normal physiological defecation mechanism can be better and faster established unconsciously in the affected children.