1, general manifestations: lower limbs and foot skin less sweaty, dry, abnormal sensation, muscle atrophy, fractures, etc., the clinical manifestations of combined diabetes and multi-organ vascular complications. Nantong Hospital of Traditional Chinese Medicine, Gong Xuchu 2, ischemia and neuropathy manifestations: decreased skin temperature, the affected foot cold, cold limbs, pale, limb arterial pulsation is weakened or disappeared, there may be intermittent claudication, etc.. When neuropathy appears, symmetrical pain and sensory abnormalities often appear, with pain in the form of pins and needles, burning or drilling, and sensory abnormalities preceding pain, often with numbness, ants, insects, fever, coldness and electric shock-like sensations, often from the end of the limbs upward, with symmetrical “glove” and “glove “-like sensory dullness, insensitivity to pain, temperature stimulation or loss, the so-called “painless foot”; can also be manifested as motor disorders, such as lower limb movement is limited, limb weakness, etc.. 3, infection: often triggered by trauma, foot, skin blisters, etc., the affected foot swelling becomes larger, skin edema, into light red or yellow, local redness and heat, ulceration, yellow discharge or pus; rapid progress, can spread to the whole foot or even calf, involving muscles, blood vessels, nerves, bones, the formation of abscess, smelly or odorless; the whole body can be accompanied by fever, chills. It may eventually develop into gangrene.