Macroglobulinemia is a malignant proliferative B-lymphoma, which is a major disease because it is more dangerous. The primary and secondary forms of the disease are usually due to the malignant proliferation of lymphoid plasma cells, which synthesize and secrete a large amount of monoclonal to macroglobulin IgM. Early stage of Wahl’s macroglobulinemia may be asymptomatic for several years, and then anemia, enlarged lymph nodes, liver and spleen, and hypermucoviscidosis syndrome gradually appear, while the renal damage of Wahl’s macroglobulinemia is commonly manifested by proteinuria, renal failure, and nephrotic syndrome, etc. Generally speaking, hematuria and high blood pressure are relatively rare. Fahrenheit’s macroglobulinemia has a greater danger, need to go to the hospital in time, under the guidance of the doctor standardized treatment.