Diseases that can cause morning stiffness include rheumatoid arthritis, osteoarthritis, carpal tunnel syndrome, etc. In the early stage, depending on the disease, there may be persistent low-grade fever, joint soreness and pain, and intermittent abnormal sensation in the wrist. Morning stiffness of joints is common in rheumatoid arthritis, which can be manifested as morning stiffness of joints, symmetrical proximal interphalangeal joints and metacarpophalangeal joints of both hands, which lasts for half an hour to more than an hour before it can be relieved, with gradual emergence of persistent redness, swelling and heat pain in the joints. Osteoarthritis can also cause morning stiffness in joints, which is usually short and not serious, and can be relieved in a few minutes. In the early stages of the disease, the signs of joint soreness and pain may appear after exposure to cold, exertion or minor trauma, and the symptoms are relatively mild. Morning stiffness of the joints may also be a manifestation of carpal tunnel syndrome. Early signs are characterized by intermittent abnormal sensation and dullness of sensation in the hands and wrists, with a gradual increase in frequency. It is mostly associated with exogenous compression, smaller carpal tunnel, and space occupation in the lumen of the canal. There are many diseases that lead to morning stiffness of joints, and there may be other causes, and their early signs are also different, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.