Leukemia nosebleeds and ordinary nosebleeds are not easy to distinguish in daily life, but can be distinguished in terms of etiology, clinical manifestations, hemostasis, etc. Specific differential diagnosis is also required through blood tests such as routine, so as to achieve improvement of nosebleeding symptoms. 1. etiology: ordinary nosebleeds are often considered to be due to overly dry nasal mucosa and brittle nasal vessels, stimulated by traumatic factors, such as collision, nostril digging, etc. The rupture of small blood vessels causes nosebleeds. Leukemia is a malignant neoplastic disease of the hematopoietic system, which causes nosebleeds due to platelet reduction; 2. However, the amount of nosebleed in leukemia patients is larger, the bleeding point cannot be found, and frequent nosebleeds occur. In addition to nosebleeds, daily skin bleeding, gum bleeding, as well as fever, weakness, swollen lymph nodes and other manifestations are also seen; 3. Hemostasis: ordinary nosebleeds are easy to stop, often using compression hemostasis method, that is, pinching the bilateral nasal flanks with both hands can relieve nosebleeds, or electrocoagulation hemostasis also has a certain effect. However, nosebleeds caused by leukemia are not easy to stop bleeding and need to be stopped by sponge filling, and if necessary, platelet transfusion can be used to improve the bleeding symptoms. Therefore, patients can make a preliminary judgment based on the frequency of occurrence, whether it is accompanied by uncomfortable symptoms and the effect of stopping bleeding, but if the situation is more serious, they should promptly seek medical examination and take targeted measures to deal with it in order to avoid adverse consequences. After the nosebleed is stopped, avoid digging the nostrils with your hands again, avoid blowing your nose hard to avoid bleeding again, and also pay attention to keeping the nose clean and hygienic.