The uterus is an important organ of the female genitalia and is a characteristic of women. The uterus is an essential organ for maintaining menstruation and female fertility under the regulation of the action of various hormones in the body; at the same time, the uterus is also an endocrine organ with complex functions, and many biologically active substances secreted by the uterus can participate in regulating local and systemic physiological and pathological processes. Therefore, hysterectomy undoubtedly brings many negative effects on the physiological, psychological and life adaptation of postoperative patients. Hysterectomy not only disrupts the dynamic endocrine balance between the premenopausal uterus and ovaries, but can also cause the phenomenon of ovarian function decline. Although hysterectomy in premenopausal women tries to preserve as much ovarian tissue as possible, the ligation of adjacent blood vessels can still affect ovarian blood flow, thus reducing ovarian function and causing an abrupt drop in serum estrogen levels and lacking a gradual adaptation process. Most women will experience varying degrees of reduced sexual function after hysterectomy, mainly in the form of lack of sexual desire, reduced frequency of sexual intercourse, and difficulty in orgasm. In the past, there were not many investigations about post-hysterectomy sexual life for various reasons, such as patients were often shy about sex and doctors had no time to care or ignore. It is now gradually recognized that the sexual harmony and sexual health of patients after hysterectomy will also involve the consolidation of marriage and family, so the problem of sexual life after hysterectomy cannot be ignored for women of any age. Now we analyze the following factors of the impact of hysterectomy on sexual life: 1. The hysterectomy destroys the uterus and vaginal nerve plexus endings and leads to reduced sexual response and difficulty in orgasm. 2. The shortening of the vagina after hysterectomy and vaginal dryness due to the decrease of estrogen level can cause painful intercourse. After hysterectomy, there is often inflammatory granulation when the vaginal stump is healed, which leads to bleeding during intercourse and painful intercourse. 4, in addition to psychological changes also affect the quality of women’s sexual life after surgery, such as fear of surgical pain, anxiety about not coming to menstruation after hysterectomy, can no longer reproduce and worry about the change in her husband’s interest in her after surgery, worry about the loss of sexual function, early aging, male change, etc.. Some patients due to excessive worry can seriously affect the harmony of conjugal and family life, affect work, can produce depression, anxiety and other mental symptoms, resulting in psychological disorders.