Premature ejaculation refers to premature ejaculation of the male partner during sexual intercourse and affects normal sexual intercourse. It is a common condition in men with abnormal sexual function, and the Chinese medicine Zhi Bai Di Huang Wan is often used to nourish yin and reduce fire (nourish yin and essence and lower fire) in the identification of Yin Deficiency and Fire Exuberance. Clinical manifestations of premature ejaculation of the yin deficiency and hyperactivity type are high libido, but premature ejaculation during sexual intercourse, accompanied by hot flashes (a burst of heat), night sweating (abnormal sweating after going to sleep, and sweating stops after waking up), five heart heat (heat in the hearts of the hands and feet, and self-consciousness of the heart and chest), dizziness, lumbar and knee soreness and tenderness (lumbar and knee soreness and tenderness), and spermatorrhea. Zhi Bai Di Huang Wan is composed of Huang Bai, Zhi Mu, Shu Di Huang, Cornu Cervi, Mudan Pi and other medicines. It has the efficacy of nourishing yin and reducing fire, and can be used for symptoms of seminal emission and premature ejaculation caused by yin deficiency and fire exuberance. The adverse reactions and contraindications of this product are not clear. If the patient is found to have premature ejaculation, it is necessary to go to the hospital in a timely manner, and standardize the treatment under the guidance of the physician’s diagnosis.