Li Shizhen said, “The phase messenger, my adjuvant, is also.” (“Materia Medica . Preface of the first volume “) although cold and hot drugs for different types of drugs, in the performance of the efficacy is not obvious commonality, but in the cold and hot common formula, when the common cold and hot drugs in the formula for a king a zuo (zuo auxiliary or anti-zuo), or a for the king a for making drugs, or the main use of its cold and hot nature to leveling cold and heat, Xie Li yin and yang, or the main use of its flavor to bitter drain Xin Tong, bitter firm Xin Yun, or the nature of the phase with a sick evil, the use of the Tohua. Cold and hot drugs can often be used as each other, there is a good role of different kinds of make. 1, to cold drugs as the main, to hot drugs for supporting or lead to make in the use of bitter cold drugs to remove heat and dampness, with a small dose of pungent and hot drugs, such as dry ginger, cinnamon and cornelian cherry, etc., not only can the bitter and spicy together, dampness evil and smooth air, but also invigorate the yang qi, such as sunshine, haze, easy to dissipate, not only will not help the heat, but also on the main medicine to remove heat and dampness have to help the work of the main medicine. Such as in the treatment of jaundice, not only with Yin Chen with soup for the treatment of Yin Huang belongs to the cold and heat, different kind of make, even if the treatment of Yang Huang, with Yin Chen, cypress, gardenia and so on clearing heat and dampness to remove the yellow at the same time, where appropriate into a small amount of dry ginger or wu juezhu and other spicy hot medicine not only can prevent the cold and cold hurt the stomach, but also can be spicy dispersal of dampness and smooth qi, accelerate the subsidence of jaundice, especially suitable for those who have a stomach plagued with moss yellow and slippery evidence. In the treatment of damp-heat stomach pain, if the tongue is slippery, in the use of Huanglian, Scutellaria baicalensis, etc. to clear away heat and dampness at the same time, you can add dry ginger 2-3g, can invigorate yang, pungent dispersal of dampness to speed up the removal of damp-heat evils. Zhongjing used Coix lacryma and epiphyllum to treat intestinal carbuncle pus has become evidence, the formula of Coix lacryma and epiphyllum is cold, resolving blood stasis and draining pus, clearing heat and removing toxins, and less hot epiphyllum to pass the yang to dissipate the knots, cold and heat, although they are different, and used to accelerate the elimination of pus and toxins. Huangbai, Zhimu and other bitter cold medicine can remove the evil heat and preserve the yin and fluids, which is called bitter firm. Qi to Jin also to, hot drugs in the dry ginger, cinnamon and other hot and spicy drugs, can pass the qi and blood, dispersal of fluid to moisten the dry, it is called Bu Jin moisten dry. Cold medicines with bitter kidney effect and hot medicines with Bu Jin Run dry effect are used together, with the former as the king’s medicine and the latter as the enabler, which is bitter, firm and pungent, and is often used in the treatment of yin injury by damp-heat in the lower Jiao, and the yin cannot be spread by the yin-liquid of the liver and kidney, which is characterized by deficiency of yin and heatiness of the liver and kidney. Such as “Danxi Xinfa” of the tiger submerged pill, cypress and tortoise board for the monarch, cypress with Zhimu clear heat and firm yin, accompanied by pungent ginger, not only to prevent the bitter cold Zhimu defeat the stomach, but also can dissipate the evil of dampness and pass the qi channel, dispersal of fluids, and with the tortoise board, so that the sweet, salty and cold tortoise board and other nourishment of liver and kidney medicines in the yin Jin to be dispersed to moisturize and nourish the sinews and bones, and deep with the “kidneys are bitter and dry, the urgent food to moisturize the”. This is in line with the purpose of “the kidney is bitter and dry, so it is urgent to eat pungent to moisturize it”. In Nourishing Kidney and Passing Pill, Huang Bai and Zhi Mu are used to clear heat and dry dampness and firm up the yin, and Cinnamon is used to induce Zhi Bai to enter into the kidney and bladder blood directly, and to pass the yang qi to help the qi, although the medicine is only 3 flavors, but it can make the dampness and heat of the lower burner clear and the fluid return, and the qi passes through the urine retention to heal, which is a good use of the different kinds of combination. The combination of sweet and cold medicines such as pollen and maitong with a few pungent and hot medicines such as appendicia and cinnamon can warm yang qi and vaporize fluids, treating the upper dryness and lower coldness. For example, in the Gua Pou Qu Mai Pill of the Jin Gui, the pollen, qu mai, and appendicia were used in conjunction with appendicia to warm the kidney yang and pass the qi, which could enhance the clearing and moistening of the pollen and the effect of the pollen, while qu mai was used in conjunction with appendicia to strengthen the effect of diuretics. A small amount of cinnamon in Paeoniae Alba Tang not only prevents bitter and cold medicines such as Scutellariae and Rhubarb from injuring the stomach and ice-vacuuming the evils of damp-heat, but also supports and transforms the damp-heat, and is used together with the bitter and acidic and slightly cold monarchical medicines Paeoniae Alba and Radix Angelicae Sinensis, with the effect of harmonizing blood, stopping dysentery and relieving analgesia. Zuo Jin Wan uses a small amount of hot and pungent Cornu Cervi Pantotrichum to dissipate liver depression, and relies on it to lead and make the monarchical drug Huang Lian not only clear stomach heat, but also enter into the liver to bitterly drain liver fire and inhibit liver qi wantonness. In this way, the combination of cold and heat, and the bitterness and pungency have a good effect of suppressing the liver and stomach. When treating exogenous heat illness, when using cold medicines to clear away evil heat, a small amount of hot medicines can be used as appropriate, especially hot medicines with yang-boosting effects, such as Radix et Rhizoma Polygoni Multiflori, Cinnamon, etc. This can not only clear away heat, but also eliminate heat. In this way, not only can clear the heat to eliminate the evil, but also can warm the sun to support the positive, used for the evidence of the evil and the positive qi has been weakened. For example, if a person who has a deficiency of yang in his body suffers from warm disease, the evil enters the heart camp, the consciousness is sometimes bright and sometimes obscure, the spots and rashes are hidden, the tongue is red with little moss, and the pulse comes to the number of deficiency. Positive gas is not enough, the evil can not reach the outside, there is a threat of collapse, in the use of rhinoceros (buffalo horn) even, winter, ground, Dan, Xuan, silver, warping such as to the treasure of Dan and other cold medicines to clear the camp through the heat, open up and wake up the spirit at the same time, often adding hot and spicy epiphyllum and ginseng in order to warm the sun and benefit from the gas, cold and heat, can promote the evil potential of the potential with the drug and out of the reach. For example, “Jin Gui” Wen Jing Tang is used to treat the syndrome of deficiency and coldness of Chong Ren and blood stasis. The hot and pungent Cornus officinalis with Gui Zhi as the monarch, to warm the meridian stasis, in addition to the use of ginseng grass in the adjuvant to benefit qi and blood, but also the bitter cold dandelion and sweet cold maitake with Colla Corii Asini to nourish the yin and blood, moistening the veins in order to increase the water line of stasis, so that stasis of blood from the Chong Ren vein down, similar to the treatment of the later generations of yin loss of yangming heat knot water line of the boat method, dandelion, maitake with the hot and cold Cornus officinalis, although the nature of the opposite, but because of the right combination, a monarch, one for the adjuvant, between them but the two are the same. The two have a synergistic effect on each other. Clinically, the more serious cold and heat evidence of evil, cast to hot or cold medicine; if the disease drug resistance, the disease does not accept the drug and the occurrence of the refusal of the grid, commonly used and the disease from the gas from the cold or hot medicine, cold and heat and to eliminate the refusal of the grid, is called anti-zo. For example, Tong Wei Si Reverse Plus Pig’s Bile Soup and Bai Tong Plus Pig’s Bile Soup, the bitter and cold pig’s bile can lead to the great pungent and great heat of the epiphyllum and dry ginger into the yin, in order to eliminate the yin’s refusal of the pungent and hot medicines. The combination of cold and heat not only has good counteracting effect, but also can harmonize the yin and yang, so that the deficiency yang returns to the yin, and the yin and yang can be connected smoothly, so that the danger of syncope can be solved.