The main causes of numbness in the fingers and toes are as follows: 1. cerebral infarction, patients with cerebral infarction can cause numbness in the hands and feet on the opposite side of the lesion, often accompanied by weakness, abnormal speech and unstable walking. 2. diabetes, diabetes can cause peripheral nerve damage, patients can have bilateral numbness in the hands and feet, symmetrical, often with glove-like or glove-like distribution of sensory abnormalities. 3. cervical spondylosis, mostly seen in patients with neurogenic cervical spondylosis, can be numbness and sensory abnormalities in one or both extremities. 4. 4, peripheral neuritis, these patients are mostly due to infection, poisoning, drugs and other reasons, can appear numbness and abnormal sensation of the extremities. 5, HIV infection, due to HIV infection of patients with peripheral nerve invasion, resulting in numbness of the hands and feet. 6, anxiety, depression, some patients suffering from anxiety, depression and other somatization disorders, can feel the hands and feet Numbness, mostly accompanied by insomnia, loss of appetite and other symptoms.