Numbness in the little toe is firstly considered as peripheral neuropathy. Due to damage to the peripheral nerves, the little toe can become numb, cold, and in severe cases, painful. The common cause of peripheral neuropathy is diabetes, which leads to demyelination-like damage to the peripheral nerves due to unsatisfactory blood glucose control, which can lead to numbness and coldness in the little toe and, in severe cases, numbness and coldness at the end of the extremities. Secondly, peripheral neuropathy can also be seen when the little toe is exposed to toxic substances such as organophosphorus, which can lead to peripheral nerve damage to the little toe, which can also cause numbness and numbness. Finally, peripheral neuropathy can also be caused by wearing shoes that are too small, resulting in compression of the little toe and damage to the peripheral nerve after poor blood circulation, which can also cause numbness in the little toe. If necessary, the patient can be given an electromyogram, and treatment can be given to nourish the nerves and improve circulation, and if necessary, acupuncture treatment can be given to improve the symptoms of numbness.