There are many causes of numbness in the big toe, the most common are lumbar spine disease, nerve injury, diabetes, etc., as follows: a. Lumbar spine disease: patients with lumbar disc herniation, lumbar spine slippage, when the compression to the spinal nerve roots, will lead to the existence of clinical symptoms of numbness in the big toe, to make a clear diagnosis, the lumbar spine general X-ray, lumbar spine CT and lumbar spine MRI examination. The diagnosis can be made clearly. Second, trauma: If local nerve injury is caused, it will also lead to the clinical symptoms of numbness in the big toe, which needs to be treated with nerve-nourishing drugs, such as methylcobalamin, and will slowly recover. Diabetes: If it causes peripheral nerve damage, it will also cause the clinical symptoms of numbness in the big toe.