Second toe numbness should first be considered due to the presence of lumbar spine disease, such as patients with lumbar disc herniation or lumbar spine lesions, resulting in patients with sensory nerve conduction disorders caused by a phenomenon. The second may be due to cardiovascular disease, such as coronary artery blockage, myocarditis and other cardiac diseases caused by the patient, resulting in peripheral circulation disorders, the patient will appear numb toes phenomenon. Then it may be caused by the patient’s trauma, or central neuropathy in the brain, such as brain tissue necrosis, brain tissue ischemia, and other causes. Patients should go to the hospital as early as possible to have brain CT, MRI and other examinations to diagnose the cause and then treat the symptoms. Patients should also pay more attention to rest in daily life and can have acupuncture or massage to relieve the symptoms, and surgery can be performed if necessary.