Clinical manifestations of leukoaraiosis.
1.Preferred population
The disease can be seen in all kinds of people in China, from adolescents to the elderly can be affected, more common in young and middle-aged people, both men and women can develop.
2.Mouth ulcers
Patients mainly manifest as repeated oral ulcers, pain, ulcer surface is deep, the bottom is mostly white or yellow, can appear in multiple parts at the same time multiple ulcers (commonly known as “mouth sores”), including the tongue, lips, palate, pharynx, etc.. Most of the ulcers can improve on their own, but they often recur, and in severe cases, the pain is so severe that it affects eating.
3. Genital ulcers
In addition to oral ulcers, patients can also develop vulvar ulcers, such as male and female genital ulcers, which can be larger and can be solitary in these areas.
4.Ocular lesions
Some patients may also show eye lesions, with redness, swelling, pain, photophobia or loss of vision and blurred vision, and one or both eyes may be involved.
5.Skin manifestations
Some patients may develop skin lesions, such as a “pimple”-like rash on the face, chest and back, or other areas, or a “boil”-like manifestation, which may improve on its own, but is prone to recurrence. In addition, some patients may have cyanosis, swelling and pain in the lower extremities, which can be touched as “bumps”, while others may have recurrent erythema in the lower extremities, which may vary in size from soybean to copper coin, and is painful when pressed. This phenomenon is called “erythema nodosum”. Other patients may have localized erythema or blisters or pustules in the eye of the infusion or blood draw, mostly within 24 to 72 hours after the injection, which is called a positive “needling reaction”.
6.Joint lesions
Many patients will have joint pain or swelling, either single or multiple joints, mostly in the joints of the lower limbs, with arm and leg pain, and in severe cases, joint effusion and synovitis.
7. Digestive tract lesions
Another common manifestation is gastrointestinal symptoms, including difficulty swallowing or chest pain when swallowing, acid reflux, heartburn, abdominal pain, diarrhea, pus or blood in the stool, or feeling a lump in the abdomen, weight loss, weight loss, and lack of appetite. “.
8. Vascular lesions
A small number of patients can have thrombophlebitis and deep vein thrombosis, and in severe cases, it can be complicated by pulmonary embolism, and patients can have shortness of breath, breath-holding, chest pain or even fainting after activity. Other patients can develop aneurysm, causing local embolism, ischemia, and hemorrhage after aneurysm rupture, which can even endanger life.
9.Nervous system lesions
Some patients may have inflexibility of hands and feet, headache and dizziness, nausea and vomiting, numbness, pain or weakness of hands and feet, and paralysis of one side of the arms and legs, and in severe cases, convulsions, rolling eyes and other manifestations similar to “goat horn”, which may be due to the damage to the nervous system caused by Behçet’s syndrome. The most commonly affected part of the nervous system is the brain stem, but also the spinal cord, cerebral hemispheres, cerebellum and cerebrospinal membrane, and brain atrophy can occur.
10. Systemic symptoms
Many patients have systemic symptoms such as weakness, poor performance, low fever and wasting.