Waking up with thoracic spine pain may be caused by extrusion of the thoracic spine, degenerative lesions of the thoracic spine, tuberculosis of the thoracic spine, bone tumors and other factors. 1. Thoracic spine extrusion: due to incorrect sleeping posture, it may lead to extrusion of thoracic spine, causing thoracic spine pain, and in severe cases, it may lead to small joint disorders, accompanied by obvious pain and activity limitation. 2. Thoracic spine degenerative diseases: such as the occurrence of thoracic disc herniation, spinal stenosis, osteophytes and other lesions, thoracic spine pain, accompanied by radiating pain in the limbs caused by compression of nerves. 3. Thoracic spine tuberculosis: If thoracic spine tuberculosis occurs, it can lead to the damage of the intervertebral space, and the symptom of thoracic spine pain occurs, which is usually accompanied by the typical performance of night sweats, fatigue, cough and so on. 4. Bone tumor: If the bone tumor of the thoracic spine occurs, thoracic spine pain can occur, and should be examined in time. Wake up thoracic spine pain may also be caused by other reasons, if the pain can not be relieved, should promptly consult the doctor to identify the cause of targeted treatment.