Age spots, known as seborrheic keratosis in clinical practice, are benign epidermal proliferative tumors common in the elderly, commonly found on the face, back of the hands, and chest and back, but can also occur anywhere on the body surface. It presents as dark, well-defined, variable-sized patches, flat papules or plaques, and some of them exist with rough surface and a feeling of adhering to the skin surface. Age spots are mainly related to skin aging, environmental factors, genetic factors and genetic mutation, which are more common in men over 40 years old and in women over 60 years old, but some young people may also suffer from this disease. 1. skin aging: skin aging and causing delayed maturation of keratin-forming cells, which leads to this condition; 2. environmental factors: sun exposure may be related to seborrheic keratosis, which mostly occurs in the Exposed parts. The skin that is exposed for a long time is more prone to photoaging due to sunlight than the skin of the body that is covered by clothes. Therefore, patients should pay attention to daily sun protection to prevent skin lesions; 3, genetic factors: cases of pancytopenia may show autosomal dominant inheritance, suggesting that the disease is related to genetic factors; 4, genetic mutations: some studies have found abnormal expression of epidermal growth factor receptors in seborrheic keratosis, and somatic activation mutations in the genes of fibroblast growth factor receptor-3.