Age spots, known as seborrheic keratoses in clinical practice, are benign epidermal hyperplastic tumors common in the elderly, commonly found on the face, dorsum of the hands, and back of the chest, but can occur on any part of the body surface. It presents as dark-colored, well-defined, variably sized spots, flat papules or plaques, some of which exist with a rough surface and a feeling of adherence to the skin surface. Age spots are mainly related to skin aging, environmental factors, genetic factors, gene mutation, this disease is common in men over 40 years old, women over 60 years old, but some young people may also suffer from this disease. 1, skin aging: skin aging and cause keratinocyte maturation delay, resulting in this condition; 2, environmental factors: sun exposure may be related to seborrheic keratosis, seborrheic keratosis occurs mostly in the Exposed areas. The skin exposed for a long time is more prone to photoaging due to sun exposure than the skin of the body covered by clothes. Therefore, patients should pay attention to daily sunscreen to prevent skin lesions; 3, genetic factors: cases of generalized damage can be manifested as autosomal dominant inheritance, suggesting that there is a certain relationship between this disease and genetic factors; 4, gene mutation: some studies have found that seborrheic keratosis epidermal growth factor receptor expression is abnormal, fibroblast growth factor receptor-3 gene there are somatic activation of mutations and so on.