Age spots on hands, clinically called “seborrheic keratosis”, also known as age warts, seborrheic warts, basal cell papilloma, is the most common benign epidermal proliferative tumor in the elderly. In addition to the hand, senile plaques are also found on the face, chest, back and other exposed areas. The lesions are initially one or several yellowish or light brown flat papules with clear boundaries and a granular surface; subsequently, they may gradually increase in size or expand with age and persistent sun exposure and inflammatory stimulation, and are generally difficult to subside on their own. However, this kind of disease has a chronic benign development, and there are very few patients with malignant changes. Age spots on the hands usually do not require special treatment, and the expansion and increase of age spots can be prevented by reducing sun exposure, avoiding long-term exposure to irritating chemicals and treating chronic skin inflammation on the hands. Some patients can use freezing, laser or electrocautery to remove the localized hyperplastic rash for cosmetic purposes. In recent years, CO2 fractional laser can be used to precisely treat age spots using thin layer ablation to achieve the desired cosmetic effect.