With the rapid development of perinatal medicine, the survival rate of high-risk newborns has increased significantly, and the incidence of brain injury has also increased accordingly. Neonatal brain injury is not an incurable disease, and most of the babies have a good prognosis if they are detected early and intervened early. The following are the common signs of brain injury in infants of different ages, and we hope to draw the attention of the parents of these infants. 1.Newborn period: Difficulty in breastfeeding, weak or persistent crying, few spontaneous movements, low or increased muscle tone, both thumbs inwardly clenched in the palm. Neonatal spasms, the child is prone to jumping and screaming or irritability, convulsions. 2.1-3 months Both thumbs inwardly retracted, hands clenched in fists, upper limbs inwardly retracted and internally rotated; inattentive to people, not gazing at the face and toys in front of the eyes; unresponsive, unable to smile and make fun of, unable to raise the head and erect the head; trunk stiffly stretched out or the whole body is soft, with asymmetric postures. 3.4-5 months: Inflexible eyes, no visual pursuit; dull expression, no reaction when teasing, unable to laugh; unable to roll over, head raised less than 90° in prone position, head erected unsteadily; trunk gradually hardens, mild corns or lower limbs are crossed, full forward or backward tilt in sitting position; grip reflexes are present, no sense of actively grasping objects. 4, 6-7 months No hand, mouth, eye coordination posture (can not see – hand grasping entrance); can not sit alone, lower limbs unsupported, supporting the station pointed foot; hand grasping objects soon after release. 5, 8-10 months can not sit straight and sit alone and free play, can not crawl; do not use one hand to grasp play, can not pinch small things, unbuttoning, change hands to play; can not send out dad, mom, da da and other double tone. 6, 11-12 months can not crawl, stand, can not step; not with people “goodbye”; can not consciously call parents.