Use ACEI antihypertensive drugs with caution in patients with hypertensive encephalopathy or RPLS, as their hypertension may be caused by renal artery stenosis. Bromocriptine tablets are contraindicated in patients with coronary artery disease and other serious cardiovascular diseases, cerebrovascular accidents, and arterial obstructive diseases; levodopa tablets are contraindicated in patients with serious cardiac arrhythmia, cardiac failure, glaucoma, peptic ulcer, and a history of convulsions; and Deltoid is contraindicated in patients with atrioventricular block, and in patients with a history of bone marrow suppression. Several adverse reactions of antihypertensive drugs: β-blockers, calcium channel blockers may lead to cardiac inhibition when used alone or in combination; ACEI common adverse reactions for hypotension, and can not be combined with potassium-preserving diuretics for a long period of time; nifedipine extended-release tablets may cause patients to develop bilateral lower limb edema; diuretics, β-blockers on the metabolism of blood lipids, sodium, glucose, uric acid will have an impact. Heart failure patients applying digoxin combined with Lipitor will increase the risk of poisoning; Lipitor is used in emergency cerebrovascular patients with hypertension; Cipro and calcium antagonist antihypertensive drugs should not be used at the same time clinically. In clinical work will often encounter patients with eruption, this time many doctors may think of giving haloperidol treatment. However, larger doses of haloperidol in patients with heart disease may lead to the possibility of malignant nerve block syndrome. Therefore, this drug should be used with full knowledge of the patient’s heart. In the acute phase of cerebrovascular disease, there will be varying degrees of elevated blood pressure, depending on the blood pressure, and sublingual cardioplegia and intramuscular reserpine, which are commonly used in the emergency department, are not suitable. Blood pressure falls too quickly will aggravate ischemia, such as the formation of watershed cerebral infarction; the use of antihypertensive drugs for patients with watershed infarction should be noted, blood pressure should be monitored, to prevent the aggravation of the condition after the fall of blood pressure. Sodium nitroprusside and nitroglycerin should be used with caution in cerebrovascular disease because (1) the lowering of blood pressure causes insufficient cerebral perfusion; (2) intracranial vasodilatation aggravates cranial hypertension. The use of nitroprusside should be strictly controlled dosage, and blood pressure changes should be closely observed. The storage time of the drug solution after configuration should not exceed four hours. Regarding the application of nitroglycerin in the acute phase of cerebrovascular disease: 1: please read the instructions of nitroglycerin carefully, and those with increased intracranial pressure are contraindicated! 2: theoretically, nitroglycerin dilates the cardiovascular vessels, and should indeed be avoided in the acute phase of cerebral hemorrhage! Cerebrovascular accident patient rehydration less sugar water: cerebrovascular accident patients brain is in a state of hypoxia, sugar water supplemented into the brain cells in a state of hypoxia will increase glycolysis, so that the accumulation of lactic acid, aggravating brain damage; cerebrovascular accident patients with heart failure can not be dehydrated with mannitol, infusion of fast aggravation of heart failure, infusion of slow does not work. Active intracranial hemorrhage and severe intracranial injury in the acute phase can not use cytarabine; vasodilator drugs used in the acute phase of cerebral infarction: large cerebral infarction in the early stage as well as ischemic cerebral vascular patients with hyperuricemia, caution with aspirin, there has been a patient with aspirin after the emergence of asthma, otorhinolaryngology diagnosis of the patient has nasal polyps. Aspirin should not be used with certain drugs, and vitamin B1 with the same, will increase the gastrointestinal response; with anticoagulant bicoumarin, easy to cause bleeding; with hypoglycemic drug D860 with the same, easy to cause hypoglycemic reaction; with adrenocorticotropic hormone, easy to induce ulcers; and methotrexate with the same, can enhance its toxicity; with tachyzoite with the same, easy to cause salicylate toxicity; aspirin and diltiazem with the combination of hemorrhage can cause bleeding The combination of aspirin and diltiazem can prolong the bleeding time, and should not be used before and after surgery. Mannitol is generally not used after ventricular drainage, mannitol in the intracranial active hemorrhage is prohibited (such as cerebral hemorrhage in the acute phase, especially within 6 hours, the application of mannitol can be aggravated by the expansion of hemorrhage), SAH patients are too dehydrated, prone to aneurysm re-rupture, subdural or external hemorrhage/fluid accumulation, it is prudent to dehydrate the drug, but the exclusion of intracranial surgery. Mannitol application of contraindications: urinary incontinence, cardiac insufficiency, intracranial active bleeding and hematuria patients. Drugs that need to be emphasized are commonly used drugs in neurology – dexamethasone, long-term use of many side effects, we all know, but still often see abuse, especially in elderly stroke patients; balance of the liquid is not added dexamethasone, insulin is not used in conjunction with vitamin C. Patients with myasthenia gravis use hormones with caution; if used, the initial period of use should be hospitalized and closely observed, because hormones can exacerbate the condition of myasthenia gravis. The mechanism is still not clear, the possible: direct inhibition of transmission at the N-M junction; by enhancing the action of cholinesterase inhibitors, promoting cholinergic crisis; so that the blood AchR antibody increase; early exacerbation and later efficacy is not related. Dexamethasone contains fluoride and should be used with caution in patients with rheumatologic disease. MG patients:Quinine, quinidine, procainamide, penicillamine, cardiac glycosides, phenytoin, lithium, tetracycline and aminoglycoside antibiotics can exacerbate symptoms and should be avoided. Meclofenoxate is contraindicated in people who are hyper-excitable and have extrapyramidal symptoms.Cytarabine is contraindicated in the acute phase of ICH. Oleprazolam and Cipro should not be used in PD patients, aggravating extrapyramidal symptoms.The approximate contraindications of PD medications:1, Antan, contraindicated in patients with glaucoma; combined with amantadine and anticholinergics, it can enhance anticholinergic effects and can cause paralytic intestinal obstruction;2, Amantadine, contraindicated in pregnant women and breastfeeding mothers; epilepsy, history of psychosis should be used with caution;3, Levodopa, glaucoma, diabetes mellitus, cardiac arrhythmia, malignant melanoma patients are prohibited; lactating women are prohibited.4, Silegiline and dulcolax can cause fatal reactions when used in combination;5, Tysudan, circulatory failure and acute infarction patients are prohibited.6, Medopa and Tysudan are prohibited. Medopa and Tysudan are contraindicated in patients with psychiatric symptoms, which has the side effect of inducing psychiatric symptoms. contraindications to drug therapy for PD are roughly summarized as follows: 1, anticholinergic drugs: Antan, Kaimajun glaucoma and prostate patients are contraindicated, the elderly patients can affect the memory function, it should be used with caution; 2, chrysotile alkylamine: history of epilepsy, confusion, hallucinations, congestive heart failure, renal insufficiency, peripheral vasogenic edema or erectile dysfunction, or peripheral vasculature. Angioedema or upright hypotension patients with caution with goldganglionamide antitremor paralysis; neonates and infants under 1 year of age or breastfeeding women are prohibited; 3, L-Dopa analogues: Medopa, Parkinin in narrow-angle glaucoma, psychiatric patients are prohibited, patients with active peptic ulcers should be used with caution; 4, DA receptor agonists: 1) pegfilgrastim 2) bromocriptine: side effects similar to those of levodopa, but Delusions and hallucinations are common, prohibited for those with a history of psychosis, recent myocardial infarction, severe peripheral vascular disease and peptic ulcers are relative contraindications3)New DA receptor agonists: Pyramisulphone, Ropinirole;5, MAO-B inhibitors: Sigitonin, mainly dry mouth, hypogastric and postural hypotension, etc., caution should be exercised in patients with gastric ulcers;6, COMT inhibitors: Answer is the United States, Cordant; 7, Traditional Chinese Medicine or Acupuncture has an adjuvant effect on PD. Avoid using sugar water when supplementing B1, and avoid using sugar water with insulin when supplementing potassium.The main role of Vit B1 is to participate in glucose metabolism in the form of coenzyme; when it is deficient, it is difficult for pyruvate to enter the tricarboxylic acid cycle for oxidization, resulting in the accumulation of pyruvate and lactic acid, and then use sugar to aggravate the lack of Vit B1, resulting in the accumulation of a large number of acids, which can induce Wernicke’s encephalopathy seizures, and clinically, it can even appear in the acute coma. In clinical practice, acute coma may even occur. In addition, when large amounts of glucose are administered, appropriate supplementation of Vit B1 is needed; if the goal is to replenish potassium, the use of sugar plus insulin will exacerbate the potassium deficiency, or at least be ineffective, because potassium is consumed by glucose metabolism. If the goal is not potassium supplementation, sugar and salt are acceptable. Adrenocorticotropic hormone should also be used with caution in suspected Vit B1 deficiency (Wernicke’s encephalopathy, athlete’s foot, chronic alcoholism, malnutrition, etc.); because of its antagonistic effect against Vit B1, which hinders the oxidation of pyruvate, it can induce Wernicke’s encephalopathy seizures, and can also lead to coma or even respiratory arrest. Cerebrolysin should not be administered in the same bottle with Balanced Amino Acid Injection. Insulin with VitC is contraindicated in the compounding table, and calf blood deproteinized extract and blood passages (danshen chuanxiong zhen) injection should be used with caution in patients with diabetes mellitus. Neurological stroke combined with diabetes mellitus patients with diabetic ketosis, diabetic nephropathy need to be prohibited metformin. 706 plasma substitute should be used with caution in patients with diabetes mellitus, and clinically encountered patients with parotid gland enlargement after use. Patients with tumors should be cautious of vitamin B12 and folic acid, which will promote tumor growth; patients with cryptococcal meningitis should be cautious of vitamin B12, which will promote cryptococcal growth; patients with tuberculous meningitis applying isoniazid need to use vitamin B6, but it should be less than the regular dosage, which will diminish the effect of isoniazid; patients with Parkinson’s applying levodopa should be cautious of vitamin B6, which will enhance the decarboxylation of peripheral effects, increase the peripheral Side effects, reduce the effect of the central nervous system. Vitamin B12 needle intramuscular injection is prohibited in patients with gout, can induce acute gout attack; gout acute period of caution with allopurinol, easy to induce gout, because the use of induced purine free from the gouty nodules, resulting in a transient increase in uric acid, but instead induced an attack aggravated. After the acute phase, insist on taking. Hormones, colchicine, or anti-inflammatory pain medications may be used in the acute phase. ATP pushed intravenously or wheated in may induce arrhythmia or cardiac arrest. Neurotrophic drugs (ATP) class used with caution in bradycardia, epilepsy patients and patients with cerebral infarction; tachycardia used with caution in patients with low potassium; calcium used with caution in patients with low potassium; hormones used with caution in patients with hypertension and diabetes mellitus; amiodarone used with caution in conjunction with cediran; renal function of poor patients with contraindication of edaravone; epilepsy patients with hepatic insufficiency used with caution with sodium or magnesium valproate, can be used with imipramine, isopropyl alcohol; hepatic encephalopathy Valium is contraindicated – inhibits respiration; Valium should be used with caution in irritability caused by respiratory failure, hepatic failure, acute alcoholism, etc.; slow rate of intravenous push of Valium is desirable; dissolving Valium in small doses in solvents such as saline or sugar will cloud the solution; Valium should be used with caution in epileptic patients with respiratory failure, and sodium valproate or magnesium valproate or sodium phenytoin can be used. Remember to push aminophylline intravenously slowly, it is better to push for more than 15-20 minutes, otherwise it may lead to cardiac arrest. Quinolone antibiotics should be used with caution in patients with epilepsy, as such drugs have the potential to cause epileptic seizures; Tylenol should be used with caution in patients with epilepsy, and can be replaced by BENENEVOL; corticosteroids are contraindicated (for adults); and cerebrolysin is contraindicated in epileptic patients. In some patients with neuromuscular blockade-related diseases, use quinolone antibiotics with caution, with the possibility of inducing epilepsy; use aminoglycosides with caution. Staphylococcus a prohibited in asthma, promote brain metabolism class with caution in epilepsy. Clinical often encountered sick brain, both epileptic seizures and intractable mental symptoms, pay attention to the control of mental symptoms prohibit chlorpromazine (can induce epilepsy). Antiepileptic drugs: Phenobarbital is a hepatic enzyme inducer, so it can make hydrocortisone, dexamethasone, testosterone, estrogen, progesterone, oral contraceptives, chlorpromazine, chloramphenicol, doxycycline, digoxin, digitalis glycosides, and phenytoin sodium, etc., when used in combination with the metabolism of accelerated efficacy is reduced. Sodium valproate can inhibit the metabolism of phenytoin sodium, phenobarbital, pemidone, clonazepam, easy to make its toxicity, so in the combination should pay attention to adjust the dose. Carbamazepine and phenobarbital, phenytoin sodium, can accelerate the metabolism of carbamazepine, so that its concentration decreased. Antidepressants, macrolide antibiotics, isoniazid, cimetidine and other drugs can increase the blood concentration of carbamazepine, making it prone to toxic reactions. Folic acid can exacerbate seizures. Seizure exacerbation caused by antiepileptic drugs: carbamazepine, phenytoin sodium, phenobarbital sodium, etc. may exacerbate cataplexy seizures; carbamazepine, phenytoin sodium may exacerbate myoclonic exacerbation; lamotrigine may lead to exacerbation of myoclonus; Tolterodine may lead to cognitive decompensation in children, low-grade fever, an absence of sweating. Phenytoin sodium can cause gingival hyperplasia, hirsutism, ugly face, unless the economic conditions are limited, the general children and female patients are not too use; Phenytoin sodium and phenobarbital will accelerate the metabolism of oral contraceptives, resulting in contraceptive failure; Sodium valproate may lead to weight gain, beauty-loving ladies or fatter people are also not recommended, if there is a suitable, you can use TOTOYA, but the weight may be lost; Pregnant women prohibited from using sodium valproate ; Cipro is contraindicated in patients with depression or Parkinson’s disease; in addition, try not to use Antan in elderly patients or patients with cognitive dysfunction. Carbamazepine has a bone marrow suppression, lower white blood cells. Epileptic patients with low blood calcium (pseudoparathyroidism, etc.) do not use carbamazepine, phenobarbital and phenytoin sodium and other hepatic enzyme inducers, because the latter can reduce blood calcium. Anti-fibrillation paralytic drug amantadine: with a history of epilepsy, psychosis, hallucinations, congestive heart failure, renal insufficiency, peripheral angioedema or upright hypotension of patients with caution; newborns and infants under 1 year of age or lactating women are prohibited. Xionin: severe cardiovascular or pulmonary disease, bronchial asthma, hepatic and renal disease, endocrine system diseases, gastric ulcer or history of convulsions and pregnant women should be cautious; narrow-angle glaucoma, suspected skin cancer or melanoma history of patients is prohibited. The use of antibiotics: β-lactams can not be paired with acidic or alkaline drugs When the infusion can only use saline to dissolve the drug, can not be dissolved with dextrose injection. Cephalosporins (especially first-generation cephalosporins) should not be used in combination with high-efficiency diuretics (such as tachycardia) to prevent serious kidney damage. Norethindrone vancomycin can produce precipitation reaction with many drugs, so other drugs should not be added to the infusion containing this product. Sulfonamide injection drugs such as sulfadiazine injection, not easy to combine with acidic drugs, such as Vb, penicillin, tetracycline, ephedrine hydrochloride, etc., otherwise precipitation of sulfonamide precipitation, meet 5% sodium bicarbonate injection, precipitation of sulfonamide precipitation. Solid dosage forms meet procaine efficacy is weakened or even ineffective, meet calcium oxide, ammonium chloride will increase the toxicity of the urinary system. Application of cephalosporin antibiotics requires temporary abstinence from alcohol – disulfiram-like reaction. Low-potassium cycle paralysis with caution with aminoglycosides and clindamycin; patients with neuromuscular blockade, such as Guillain-Barre syndrome, anti-infective drugs can not be used with clindamycin, because clindamycin can block the neuromuscular junction. Azithromycin and theophylline should be used with caution, and concomitant use of benzylacetone will increase the efficacy of anticoagulants, can elevate the level of digoxin and ergotamine or dihydroergotamine can lead to acute ergot toxicity symptoms: severe peripheral vasospasm and sensory retardation, can increase serum levels of carbamazepine, terfenadine, cyclosporine, phenytoin sodium. Levofloxacin can cause abnormalities in blood glucose and liver function. Caution should be taken when quinolone is renewed with salvia, which can result in flocculent precipitation; ampicillin may also cause refractory drug rash in patients. 12 types of drugs that can not be combined: eugenol and aspirin; anti-inflammatory pain and aspirin; gastroschisepsis and multi-enzyme tablets; Litetracycline and ephedra; oxytetracycline and Bohol pills; fast-acting typhoid capsules and antipyretic pain relievers; antipyretic pain relievers and cold and heat relief flush; Huanglianxu HCl and Niu Huang Xieyue Pills; sulfonamides and acidic herbal medicine Shenqu; broad-spectrum antibiotics and concentrated vitamin A; erythromycin and Andrographis paniculata; antimicrobials and drugs supplemented with calcium , aluminum and iron medicines. Absolute contraindications to Gastroflexan include pheochromocytoma, breast cancer after chemotherapy; Gastroflexan and antispasmodic drugs can not be used in combination, and if they are used in combination, they will counteract the effect of Gastroflexan. There is a possibility of hallucinations after the application of metacyclomidine in the elderly. Gastric ulcer patients should be cautious to use Petasidine. Cimetidine should be used with caution in acute cerebrovascular disease to prevent acute gastric mucosal lesions; in severe cases, it can be replaced with omeprazole for sedative push, and in mild cases, it should be taken orally. Because it can pass the blood-brain barrier, it has a certain degree of neurotoxicity, the more common are dizziness, headache, fatigue, drowsiness and other symptoms. A small number of patients may have restlessness, dull sensation, slurred speech, sweating, localized convulsions or epileptic seizures, as well as hallucinations, delusions and other symptoms; there may be bradycardia, facial flushing and so on. There may be bradycardia, facial flushing, etc. Occasionally, there may be a sudden drop in blood pressure, atrial premature beats, and cardiac and respiratory arrests when injected intravenously. Lipid-lowering statins and betas should not be used in combination; statins can cause rhabdomyolysis, when patients taking statins develop myalgia, muscle weakness, creatine kinase significantly increased, the drug should be discontinued; Vincristine is not used in patients with bradycardia. Transient aphasia occurs after lidocaine is applied in large quantities. Luminal sodium is contraindicated in patients with severe hepatic and renal dysfunction, bronchial asthma. 10% chloral hydrate is contraindicated in arteriosclerosis, nephritis, liver disease. Opium poppy is contraindicated in patients with atrioventricular block; nimesulide (Prevacid) can cause facial edema. Care should be taken when using anti-inflammatory cholestatic tablets in elderly patients with small mud-like gallstones, as there is a risk of bile duct impaction leading to acute biliary pancreatitis. Application of warfarin for anticoagulation, such as pulmonary thromboembolism, and atrial fibrillation in patients with long-term anticoagulation can be used warfarin oral, and need to detect the INR value. When applying warfarin, it should be noted that the early application of warfarin leads to temporary, transient hypercoagulability (protein C, protein S depletion), so it is necessary to combine warfarin with subcutaneous heparin anticoagulation in the first three to five days of the start of warfarin. This is partly due to the slow onset of action of warfarin and partly due to the transient, temporary hypercoagulability it causes. Although it is tempting to antagonize the effect of warfarin by administering vitamin K in the case of bleeding caused by warfarin, this may cause problems with subsequent anticoagulation. Therefore, the drug can be discontinued at this point. Continue to observe, and if the bleeding is heavy and active, consider the use of fresh plasma and supplementation with coagulation factors. Low molecular dextrose may cause patients to develop refractory drug rash should be used with caution.