Cat-scratch disease is caused by infection with Hansenbachia. The pathogen is mainly caused by contact with domestic animals such as cats or by scratching or biting the skin. Typical clinical features are primary skin lesions and enlarged lymph nodes, which are generally benign and self-limiting. However, a few patients may develop severe systemic damage, such as granulomatous hepatitis, hepatosplenomegaly, neuritis and meningoencephalitis, etc. The entire course of the disease is 1 to 4 months. The incubation period is generally 3-10 days from scratching to the appearance of the rash, and about 2 weeks from local lymph node enlargement. The entire course of cat-scratch disease is mostly within 4 months, but there are a few up to 1 to 64 years, suggesting the existence of chronic cat-scratch disease. 1, primary skin damage Typical cases from about 3 to 10 days after scratching 64% to 96% of patients will appear primary skin damage, visible maculopapular rash, erythema nodosum, herpes, petechiae, urticaria, annular erythema and pustular rash, mostly seen in the hands and feet, forearms, calves and face, etc., generally lasts about 1 to 3 weeks, individual can heal after 1 to 2 months. The skin remains transiently pigmented or crusted, but does not leave a scar. The hemangioma lesions will occur one after another in 1 to 2 months, manifesting as small skin nodules of 0.5 to 2.0 cm in size, which can last for several months. Local lymph node enlargement occurs in the lymph nodes in the drainage area about 10-15 days after scratching infection, mostly in the head and neck lymph nodes, followed by axillary and inguinal lymph nodes, and preauricular, postauricular, submandibular and supraclavicular lymph nodes can also be involved. They are about 1 to 8 cm in size, mostly painful and moderately hard, and 10% to 25% of them become septic. It is often self-limiting, but can last for 2 months, and the swelling does not go down until more than half a year in some cases. 3. Systemic manifestations 50% of cases have fever, most of them are mild, often below 39℃, about 9% of cases can have high fever. At the same time, the patient often has flu-like symptoms such as weakness, lack of appetite, vomiting, cough, headache, weight loss and sore throat. When the lymph nodes suppurate, the symptoms of systemic toxicity are obvious, and the symptoms disappear after the pus is broken. 4. Central or peripheral neurological symptoms About 2% of cases show symptoms of central nervous system involvement, such as encephalitis, meningitis, spinal radiculitis, optic retinitis, polyneuritis or paraplegic myelitis. Most cases occur 4-6 weeks after lymph node enlargement, with increased cerebrospinal fluid lymphocytosis and increased protein. The EEG is abnormal in most cases, and full recovery takes several months. The disease is often more severe in those with immunodeficiency underlying disease. 5, other manifestations In recent years, some syndromes have been reported to be associated with cat-scratch disease, called atypical cat-scratch disease clinical manifestations, mostly seen in pediatric patients. Treatment 1, anti-pathogenic treatment A variety of antibacterial drugs are effective for the disease, the first choice is gentamicin and sulfamethoxazole/methoprene (compound sulfamethoxazole, SMZco), gentamicin dose of 5mg/(kg・d), divided intramuscular injection or intravenous drip, a course of 5 days; sulfamethoxazole/methoprene (SMZco) in sulfamethoxazole (SMZ) 30 ~ 60mg/(kg・), TMP6 ~ TMP6 ~ TMP6 ~ TMP6. times), TMP6～12mg/(kg・times), 2 times/d, orally, for 7 days. Other aminoglycosides such as amikacin, tobramycin, netilmicin, β-lactams such as ampicillin, cefoxitin, cefotaxime, ceftazidime and other drugs such as ciprofloxacin, rifampin, erythromycin, doxycycline, etc. are all sensitive to Hanselbarton and can be used. Patients with serious illnesses such as concurrent encephalitis or patients with immunodeficiency base should be treated with two drugs with stronger antibacterial effects in combination. 2, symptomatic and local treatment According to different conditions, symptomatic treatment can be appropriate, such as the application of some antipyretic, analgesic and other drugs; clean the primary skin damage, local wet compresses, etc.. If the lymph nodes become septic, multiple aspirations of pus can be used, and generally no incision and drainage is made. Prevention Do not keep or play with cats, dogs and other pets. Immediately after being scratched by cats and other animals, treat with iodine or mupirocin (mupirocin) ointment (mupirocin) for topical disinfection and observe the local lymph nodes regularly. Patients generally do not need to be isolated.