1, diuretics diuretic decongestion For nephrotic edema is mainly tab diuretics including furosemide, bumetanide and dragosemide, when applying this drug pay attention to prevent the occurrence of hyponatremia, hypokalemia and hypochloremic alkalosis. 2, osmotic diuresis Through a transient increase in plasma colloid osmotic pressure, it can make the water in the tissues reabsorbed into the blood, in addition they pass through the glomerular filtration, resulting in a hypertonic state in the renal tubules, reducing the reabsorption of water and sodium and diuresis. Usually, low molecular dextrose or 706 plasma substitute is administered intravenously once every other day, followed by the addition of tab diuretics to enhance the diuretic effect. However, it should be used with caution for urine volume less than 400ml per day, which can induce osmotic nephropathy and lead to acute renal failure. 3.Increase plasma colloid osmotic pressure Intravenous infusion of plasma or plasma albumin can increase plasma colloid osmotic pressure, promote water reabsorption in tissues and diuresis, and the effect of diuretics after protein infusion will be better. Since the imported albumin will be excreted in the urine within 24~48 hours, it can cause glomerular hyperfiltration and tubular hypermetabolism, resulting in damage to the epithelial cells of the dirty glomerular layer and tubular epithelial cells and promoting interstitial fibrosis. The use of diuretics can be considered in patients with severe hypoalbuminemia, high degree of swelling and oliguria when diuresis is necessary. The principle of diuresis in nephrotic edema is that it should not be too fast or too violent, so as not to cause insufficient effective blood volume, aggravate the tendency of blood hyperviscosity and induce thrombotic and embolic complications.