Patients with kidney disease sometimes have some atypical clinical manifestations, such as back pain and weakness, loss of appetite, etc. They often mistakenly think they have stomach disease and go to the gastroenterology department. The most typical manifestations of kidney disease are hematuria, proteinuria, edema, urinary routine will appear with urine occult blood and urine protein, patients with urine protein will have more foamy urine, patients with edema in the early stage may show double eyelid edema or facial puffiness, gradually will aggravate to cause double lower limb edema or even generalized edema. In addition, when renal failure occurs in kidney disease, there are also manifestations of several systems, such as hypertension and heart failure in the cardiac system, and patients may experience headache, panic, chest tightness and difficulty in breathing. The digestive tract may also develop peptic ulcers or even gastrointestinal bleeding, which may manifest as abdominal pain, vomiting blood, and black stools. The hematologic system may develop anemia and abnormalities in coagulation. Finally, patients may also develop some internal environmental disorders, such as high potassium, low calcium, high phosphorus, metabolic acidosis, etc.