The symptoms of edema in patients with kidney disease are usually mainly edema of the upper eyelids or the whole face, and some patients with more severe disease can develop generalized edema. The pathogenesis of edema in patients with kidney disease is mainly due to the decrease in glomerular filtration rate caused by kidney disease, while the tubular reabsorption function is normal at this time, resulting in a state of globular imbalance that causes edema symptoms. Also, water and sodium retention in the body can be caused by a decrease in glomerular filtration rate. The most common cause of upper eyelid edema in patients is kidney disease. In addition to kidney disease, liver disease, heart disease, malnutrition, and many other conditions can also lead to symptoms of upper eyelid edema. Therefore, many clinical tests also need to be perfected for differential diagnosis.