The immune disease of round or oval lip erythema is more frequent in the life of female friends, and the damage of the disease should not be underestimated, once the attack of the disease, the patient’s pain is unimaginable. However, there are many female lip round or oval erythema patients who do not have a clear understanding of the harmful performance of the disease, so they often ignore the existence of the disease when it comes, and miss the treatment of the disease. Clinical diagnosis: 1, female lip round or oval erythema patients with gastrointestinal lesions in all parts of the gastrointestinal tract can be involved. About 25% of patients can have abdominal pain, diarrhea and vomiting. It is more common in children than in adults and often occurs at the beginning of the disease or during the active phase. Some patients have hepatosplenomegaly and may have increased serum transaminases, but jaundice is rare. 2. Menstrual disorders. Menstrual disorders are common in early, active patients. Early, delayed, reduced or significantly increased menstrual flow are present. Stillbirth or miscarriage may occur in those positive for anti-cardiolipin antibodies. Occasionally, pelvic effusion may be detected during ultrasound examination, suggesting the presence of pelvic plagiocele. 3. Mucosal ulcers and alopecia. About 20% of female patients have mucosal damage involving the mouth, lips, tongue, cheeks, nose and cavity with painless mucosal ulcers. There may be pain if there is secondary infection. Patients with discoid lupus erythematosus are prone to hair loss. In addition to hair loss caused by inflammation at the rash site, other parts of the body may also lose hair, not only hair, but also eyelashes, eyebrows and body hair. 4, ocular lesions, some patients have fundus changes, including fundus hemorrhage, papilledema, retinal exudate with oval-like round white hyaline, which is the product of swelling and deformation of retinal nerve fibers secondary to small vessel embolism, which can cause visual impairment. With remission, these changes can disappear. Other intravitreal hemorrhage, sclerochoroiditis, etc. 5, joint pain, more than 90% of patients with round or oval lip erythema have arthralgia, which may occur in all disease stages. Some of the joint pains have appeared several years before the onset of the disease, and some of them have swelling of soft tissues around the joints, tenderness and fluid accumulation, showing acute arthritis.