Patient: Large blisters on the back of hands and face. It is said to be erythema multiforme, and topical centipede ointment is used. I would like to ask if erythema multiforme can be cured? What kind of medication do I need to take internally and apply externally? Is it likely to recur? Zou Xianbiao: In more than 50% of erythema multiforme cases, the cause is unknown. Most of the other cases are caused by infectious diseases or by medications. Almost any kind of drugs can induce erythema multiforme: penicillin, sulfonamides and barbiturates, phentermine, antipyretics, dextran or carbamazepine are the most common. Bovine pox, BCG and polio vaccines have also triggered erythema multiforme. In addition to herpes simplex virus, coxsackievirus, measles virus, echovirus and poliovirus can be used as antigens to induce the disease. Bacterial infections are mainly septicococcal infections, which act as antigens and cause disease. They include Streptococcus haemolyticus, Staphylococcus brucei, Corynebacterium brucei, Corynebacterium diphtheriae, Corynebacterium denticulosis, etc. Mycoplasma is a pathogen that causes erythema multiforme. In addition, many doctors and scholars have studied the relationship between immunity and erythema multiforme and believe that immune factors are also a possible factor in the development of erythema multiforme. In addition, the disease can be triggered by mental stress, excessive fatigue, food allergy, focal infection and cold. If the cause can be found, it should be treated, removed or avoided. Mild erythema often does not require treatment. The exact cause of your erythema needs to be determined by a dermatologist based on your medical history. A treatment plan will then be developed accordingly.