Rheumatoid arthritis patients with calf pain are often clinically treated with non-steroidal anti-inflammatory drugs, antibiotics, glucocorticoids and other drugs. Rheumatoid arthritis is a common clinical manifestation of rheumatic fever, which often involves large joints and is nomadic, and mostly does not leave joint deformities. Rheumatic fever is due to group A hemolytic streptococcal infection and requires active treatment. Rheumatoid arthritis treatment commonly used non-steroidal anti-inflammatory drugs such as ibuprofen, etc., on the calf rheumatic pain relief effect is remarkable. Active removal of streptococcal infections is also required, and beta-lactam antibiotics such as penicillin are commonly used. In addition, if the effect of non-steroidal anti-inflammatory drugs is not good for patients, you can use such as prednisone, methylprednisolone and other glucocorticoids and other treatment. The above drugs need to be used in accordance with medical advice, rheumatoid arthritis patients are recommended to regular hospitals rheumatology and immunology departments and other related departments, in accordance with medical advice.