Liver transplantation is the only effective means to cure various end-stage liver diseases, and its indications can be summarized into the following four categories: 1, liver parenchymal diseases: post-hepatitis cirrhosis, alcoholic cirrhosis, acute liver failure, chronic active hepatitis, congenital liver fibrosis, cystic fibrosis, multiple liver cysts, neonatal hepatitis, Bou-ga syndrome and severe, difficult recurrent liver trauma, etc.; 2. Liver tumors: benign liver tumors such as multiple hepatic adenomatosis and giant hepatic hemangioma are indications for in situ liver transplantation if they exceed the scope of hepatic trilobar resection; primary malignant liver tumors such as hepatocellular carcinoma, cholangiocarcinoma, hepatic hemangioendothelial sarcoma, melanoma, etc. with extensive lesions or combined cirrhosis, where the lesions have not yet invaded extrahepatic tissues; 3. Cholestatic diseases. Including primary biliary cirrhosis, sclerosing cholangitis, secondary biliary cirrhosis, familial cholestasis, congenital biliary atresia, etc.; 4, congenital metabolic disorders: including copper accumulation disease (Wilson’s Disease), hemochromatosis, familial non-hemolytic jaundice, glycogen accumulation syndrome, hepatomegaly, etc.