Whether liver transplantation should be done for liver cancer has always been a problem faced by patients and their families, especially after hearing the news that many liver cancer patients with liver transplantation have died of postoperative recurrence, which has increased the doubts. So, should we choose liver transplantation or not? Overall speaking, the efficacy of liver transplantation is chosen for various liver cancers due to all other treatments. First of all, for small liver cancers, the risk of recurrence after liver transplantation is very small, and the patients can survive for a long time after transplantation; even for large liver cancers, without transplantation, the patients will not be treated effectively, and most of them have a survival time of 3-6 months, while transplantation can prolong the survival time and improve the quality of life. Some celebrities reported by the media died after liver transplantation mainly due to the fact that these patients were patients with large liver cancer, and the timing of transplantation was too late, so the high recurrence rate after surgery is understandable. At present, it is believed that the recurrence of liver cancer after liver transplantation is mainly related to the following factors: tumor diameter, number of tumors, degree of pathological differentiation, presence or absence of vascular infiltration, and presence or absence of lymphocyte reaction. Those with large tumors, multiple tumors, low degree of cell differentiation, accompanied by vascular infiltration without lymphocyte reaction have high malignancy and relatively high chance of postoperative recurrence. Since only the number and size of tumors and the presence or absence of large-vessel thrombus can be determined preoperatively, it is now mostly recommended to determine the risk of postoperative recurrence and prognosis based on the diameter and number of tumors and the presence or absence of large-vessel thrombus. For patients with single tumor diameter less than 5cm, the number of multiple tumors not more than 3 and the maximum diameter not more than 3cm, the chance of recurrence is low, which is a good indication for liver transplantation; for those who have more than this criterion, the survival time without transplantation is about half a year, and transplantation can prolong the survival time and improve the quality of life, so transplantation can be considered if there are enough donor livers and the economy permits it. Hepatocellular carcinoma patients should be treated with chemotherapy during and after surgery, and the application of immunosuppressants should be individualized, and the dosage should be reduced as much as possible under the premise of avoiding rejection, so that the recurrence of the tumor can be avoided and delayed to the greatest extent.