Cirrhosis causes pleural effusion due to hypoproteinemia and decreased colloid osmotic pressure, which can be treated with extraction of pleural effusion, albumin supplementation and diuresis. Cirrhosis is a disease caused by chronic fibrosis of the liver, pseudolobules and regenerative nodule formation from various causes, causing portal hypertension and hepatic decompensation. When the liver function is reduced, it can cause digestive hypoplasia, malabsorption, decreased appetite, nausea, anorexia, etc., resulting in decreased dietary intake, decreased protein intake, causing malnutrition, decreased liver function causes decreased protein synthesis, prone to hypo-proteinemia, decreased colloid osmotic pressure in the pleural capillaries, and the formation of pleural effusion. Liver is the place of transformation and inactivation of hormones, the inactivation of antidiuretic hormone is reduced, which can aggravate the formation of pleural effusion. In the treatment of cirrhosis, active treatment of the primary disease and improvement of liver function is the key to treatment. A large amount of pleural effusion can be aspirated by thoracentesis to reduce the pleural effusion, and at the same time, human albumin infusion is given to improve the colloid osmotic pressure, furosemide and spironolactone diuretic to reduce the pleural effusion. If there is cirrhosis pleural effusion, it is recommended to consult a doctor in time, under the guidance of a professional physician active treatment, so as not to delay the condition.