Question: Hello! I am 37 years old, in December 08 I was found: chronic cervical and endocervical inflammation with erosion, squamous, (6 points) visible focal CINI-11, (3.12 points) mild atypical hyperplasia of squamous epithelium, suspected combined HPV infection, on February 24, 09 I had a cervical LEP, until April 16, 10 TCT review, colposcopy saw: thin white acetate epithelium, opaque The cervical area is hypertrophic and smooth, with multiple nasal sacs and spotty bleeding on the surface. Can I be cured of this problem? How should I treat it? CIN (cervical intraepithelial neoplasia) is a group of precancerous lesions associated with cervical cancer, including CIN1, also known as mild atypical hyperplasia, CIN2, also known as moderate atypical hyperplasia, and CIN3, including severe atypical hyperplasia and carcinoma in situ (CIN2 and above are also known as cervical high-grade intraepithelial neoplasia). Moreover, it usually takes a relatively long time from the infection of high-risk HPV to the occurrence of cervical cancer, which usually takes about 10 years to go through persistent HPV infection → CIN stage → cervical cancer, which provides the premise and foundation for the prevention of cervical cancer. Timely diagnosis and treatment of precancerous lesions is currently an important measure to prevent and stop the occurrence of cervical cancer. How to screen out cervical precancerous lesions as early as possible, further examine and treat women with abnormal results, and block the lesions in pre-cancerous stage? It mainly relies on cervical exfoliation cytology (preferably thin-layer liquid-based cytology), high-risk HPV testing, and biopsy pathology under colposcopy for women with suspicion. For those who are not satisfied with colposcopy, cervical canal scraping, cervical conization, and electrocycloplegia (LEEP) for pathological examination are also required for final diagnosis. Since CIN lesions have a certain degree of “reversal”, that is, the possibility of a natural return to normal without medical intervention, for CIN1, since a significant proportion of patients can return to normal naturally, it can be observed, and after observation, if the lesion still persists or develops, LEEP local excision is feasible. CIN1 patients tested for hTERC gene, if the gene has abnormal amplification, suggesting the possibility of lesion progression, then physical therapy or LEEP and other surgical treatment, if the gene does not have abnormal amplification, then the possibility of “reversal” to normal, it is recommended to follow up and observe; CIN2, mainly conization such as LEEP treatment, etc. For young patients with fertility requirements, they can also be observed or decided by hTERC gene test results whether to observe or to have local excision; CIN3 patients, compared with CIN1 and CIN2, have a higher possibility of developing into cervical cancer and are often treated by surgical excision such as LEEP, cervical cold knife conization or hysterectomy according to the patient’s age. With these means, it is often possible to cure CIN and prevent it from developing into cervical cancer. For postoperative CIN patients with preserved uterus, they should be followed up closely after surgery, including regular cervical cytology and HPV testing, and colposcopic biopsy if necessary. For those with more than 3 consecutive normal examinations, the follow-up interval can be extended appropriately, and those with more than 2 years of follow-up will be the same as the normal population. This article is authorized by Dr. Guo Ruixia.