What is hpv is a double-stranded DNA virus, is called human papillomavirus, is one of the most common sexually transmitted pathogenic microorganisms, through the skin or mucous membrane microscopic injury, into the contact person mucosa, stimulate epithelial cell proliferation, can cause human malignant tumors and warts. HPV infection is a necessary prerequisite for the development of cervical cancer. Genotyping: High-risk types mainly cause external genital warts, external genital cancer, cervical cancer and HSIL. Characteristics of infection: Prevalence: 80-85% of women with a history of sexual intercourse are infected. Transient: about 90% of infected patients have the virus disappearing spontaneously in 1-2 years without obvious clinical manifestations. There are regional differences in the type of infection: HPV type 45 is common in western Africa, HPV types 39 and 59 are mostly found in the Americas, and HPV types 52 and 58 are detected at a higher rate in Chinese women. The type of infection is related to the pathological type of cervical cancer: HPV 16 predominates in cervical squamous epithelial cell carcinoma, while cervical adenocarcinoma and adenosquamous cell carcinoma hpv18 account for 56% and 39%, respectively. High-risk factors for HPV: multiple sexual partners or sexual partners with multiple sexual partners, early sexual activity (early sex, early marriage), sexual partners of sexual partners with cervical cancer, previous or ongoing HPV infection of the genital tract HPV, HIV infection, people on immunosuppressive therapy, smokers, drug addicts, history of cervicitis, endometrial cancer, vaginal vulvar cancer, low socioeconomic class.