Cervical cancer has become the malignant tumor with the highest incidence rate in female reproductive system, and the incidence trend is gradually getting younger. In recent years, the stars Anita Mui and Li Yuan Yuan died of cervical cancer, which makes cervical cancer come into the sight of more women, and it is urgent to pay attention to cervical health. I. Importance of cervical screening Cervical cancer has about 500,000 new cases every year, of which 78% are in developing countries and about 130,000 in China. About 200,000 women die of cervical cancer every year, about 20,000-30,000 in China. For this reason, the widespread availability of cervical cancer screening in developed countries has played a key role in effectively reducing its incidence. How to choose the right cervical cancer screening program In the past 60 years, the main method to prevent cervical cancer is cytology-based screening method, which is known as TCT, to detect high-grade lesion cells and take therapeutic measures to stop the development of cervical cancer. However, relying on TCT alone, its sensitivity in identifying high-grade lesions is poor, and it can only detect those with true pre-cancerous lesions, not those who are likely to progress to precancerous lesions. Thankfully, one study found that 99.7% of cervical cancers are associated with persistent infection with high-risk HPV viruses. TCT combined with HPV testing is now commonly used to rule out cervical lesions. Combined screening has a higher and longer term negative predictive value of over 99% with both being negative! Advantages of combined screening: Combined screening allows early detection of CIN3 and cancer Combined screening is more likely to detect adenocarcinoma in situ than cytology screening alone Double negative can increase the screening interval Examination method: TCT and HPV are both non-invasive tests, in which the cervical cells and their infected HPV virus are taken by a professional doctor with a special soft brush and tested by laboratory personnel. All women who have sexual intercourse may have persistent HPV infection which may lead to cervical lesions, so women who have sexual intercourse for more than 3 years should have regular TCT screening. People over 30 years old can consider combined HPV+TCT screening for early detection of lesions or high-risk factors and early treatment to interrupt the occurrence and development of cervical cancer and precancerous lesions. However, those with suspicious symptoms do not need to consider the age factor. Note before screening: Avoid sexual intercourse 24 hours before screening; Do not perform vaginal douching and vaginal medication 24-48 hours before screening; Avoid examination during menstruation.