Premature ovarian failure (POF), also called primary ovarian insufficiency or primary ovarian dysfunction, is a syndrome of amenorrhea before the age of 40 years accompanied by low sex hormone levels and elevated pituitary gonadotropins. The majority of POF is idiopathic, i.e., there is no primary disease causing ovarian insufficiency, but some patients have genetic causes, infections, specific enzyme deficiencies, or metabolic syndromes.The overall incidence of POF is about 1% in women under the age of 40 years, whereas premature menopause, which is defined as the loss of menstruation between the ages of 40-45 years, occurs in about 5% of women. How long a woman can menstruate in her lifetime is determined by the number of eggs in reserve in the ovaries, and a woman’s egg reserve is limited in her lifetime, so all of us will experience amenorrhea due to egg depletion, which we call menopause. The average age of menopause in normal women is around 50 years old, and menopause before 40 years old is called premature ovarian failure, and the incidence of premature ovarian failure varies greatly from region to region, with a possible incidence of 0.88% to 14.6%. The common causes of menopause due to premature ovarian failure include insufficient egg reserve (e.g., partial deletion or chimerism of sex chromosome, gene mutation, etc. can lead to insufficient number of eggs and premature failure), rapid depletion of eggs due to certain chronic or wasting diseases that lead to early failure, environmental factors such as physical, chemical, radioactive, viral, alcoholism and smoking that affect the depletion of eggs, and ovarian tumor that destroys the ovarian tissue or surgical removal of both ovaries. Bilateral removal of ovaries. At present, various malignant tumors (e.g., hematological diseases, etc.) in the treatment, due to the high dose of chemotherapeutic drugs and radiotherapy on the ovarian function of the damage, resulting in some young patients to occur in premature ovarian failure, especially hematological disease bone marrow transplantation of women, almost all patients will occur in the ovarian function of the impaired or premature failure. Also patients with rheumatic immune system disorders, which also require the use of immunosuppressive drugs, lead to premature ovarian failure in these patients. For premature ovarian failure, a definitive diagnosis must be made, and the most important diagnostic indicators are blood follicle stimulating hormone FSH>40IU/L and estradiol E2<20-30pg/dl. Patients with premature ovarian failure enter menopause 10 years or more earlier than the average woman, and the low estrogen can lead to hot flashes and sweats, sleep disturbances, depressed mood, difficulty in sexual intercourse, painful intercourse, low libido , recurrent urinary tract infections, susceptibility to osteoporosis and osteoporotic fractures, increased risk of cardiovascular system diseases, and a significant decrease in quality of life. If there are no contraindications to the use of sex hormones, it is recommended to receive sex hormone supplementation therapy in a regular specialized hospital.