Premature ovarian failure may recover on its own after discontinuing medication if it is caused by pharmacologic factors, but it basically does not recover on its own if it is caused by other factors that lead to premature ovarian failure before the age of 40. Premature ovarian failure refers to the failure of ovarian function, resulting in amenorrhea before the age of 40, the specific causes include genetic and immune factors, medical damage, as well as the use of certain drugs. If it is caused by certain medications, the symptoms are mild and may recover on their own after stopping the medication. However, if it is caused by other factors, once it occurs, it is unlikely that it will recover by itself, and it can only be treated with medication or by adjusting one’s physical condition to keep the premature ovarian failure from continuing to develop, and it is basically impossible for it to return to normal on its own, without any intervention. Patients can follow the doctor’s instructions and use estrogen-progestin replacement therapy, ovulation promotion therapy, immunotherapy, etc., according to their own conditions, and take appropriate vitamin D and calcium supplements to prevent osteoporosis caused by premature failure. In addition, in the active treatment at the same time, should be appropriate physical exercise, early to bed and early to rise, eat a light diet, eat more vegetables and fruits, avoid spicy and stimulating food, quit smoking and drinking, keep a good mood, and learn to reduce stress.