Most patients with premature ovarian failure hope to still maintain a normal menstrual cycle, so how exactly do you take the medication? Let’s learn more about it below. A hormone replacement program that mimics a normal physiological cycle involves adding progestin to estrogen for 10 to 14 days a month, then stopping the medication for 2 to 7 days. However, taking estrogen and progestin separately can cause a lot of inconvenience to patients, who can easily take them by mistake or miss them. Now there are some natural estrogen and progestin compound preparations, such as Clomid and Fentanyl. The advantage is that it is convenient to take, although it is not conducive to individualized adjustment, but it is convenient to take? and can meet the requirements of most patients. Specific medication: Clomid: 1 tablet daily for 21 days without interruption. Take 11 white tablets (containing estrogen) first, followed by 10 light orange-red tablets (containing estrogen and progestin), and stop taking them for 7 days after 21 days. Some patients have asked if they should continue to take the medication if they notice bleeding during the last 10 light orange tablets. The Clomid Post 10 tablets contain mainly progestin, which is designed to allow the lining to peel off and promote menstruation. If the bleeding is just a few drops, then continue to take the medication. If the bleeding reaches a menstrual level, stop the medication and start the next cycle after 7 days. Fenbuterol: 28 tablets, one tablet per day, 14 tablets (containing estrogen) and 14 tablets (containing estrogen and progesterone) for 28 days, start the next course of treatment on the 29th day and continue taking the medication without interruption. You should continue to take the medication even when you have your period. You should not say that you will stop taking the medication, as it may cause abnormal bleeding. In addition, daily calcium supplementation of 1000~1500mg is recommended during the hormone replacement process. 30 minutes of sun exposure per day and regular weight training are also effective ways to maintain bone health and are more effective in maintaining bone mineral density. Review and follow-up: See the article “Menopausal hormone therapy must be reviewed regularly to adjust medication” for more details.