Premature ovarian failure prevention and treatment methods are as follows: 1, estrogen therapy for various types of high gonadotropin amenorrhea, estrogen therapy can not only alleviate the symptoms of vasodilatation instability caused by the reduction of estrogen in some patients, and can prevent organ atrophy, osteoporosis and cardiovascular disease caused by lipid metabolism disorders. Stimulating hormone preparation, method and dosage should be selected according to the patient’s age, symptoms, the presence or absence of cyclic menstruation and fertility requirements. 2, estrogen-progestin sequential method Young women, no reproductive requirements: for only “menstruation” requirements of childbearing women, the use of artificial cycle or the application of Clomid. Young women with fertility requirements: use a larger dose of estrogen to maintain uterine development and suppress FSH to normal level in a short period of time, and stop the drug periodically in anticipation of the resumption of ovulation. Ovulation and pregnancy rates are higher with estrogen therapy for less than 1 year of amenorrhea than with amenorrhea for more than 1 year. 3, estrogen or estrogen-progestin application to control menopausal symptoms Long-term use of estrogen can prevent osteoporosis caused by low estrogen and cardiovascular symptoms caused by lipid metabolism disorders, to prevent vaginal atrophic changes. It is suitable for women over 40 years of age who have no requirement for childbearing. In order to prevent the cumulative effect of estrogen on the endothelium, progesterone should be used regularly to retreat. 4.Treatment of etiology and prevention The ovarian surgery program for young patients is based on the principle of preserving as much healthy ovarian tissue as possible. Actively treat autoimmune diseases.