1.Commonly used intranasal spray hormones The commonly used intranasal spray hormones in clinical practice include: rhinocort (budesonide), colecalciferol (fluticasone propionate), Bierno (tretinoin), endosulfan (mometasone furoate) spray, etc. 2.Safety of intranasal spray hormone Intranasal spray glucocorticoid is an effective method for the treatment of allergic rhinitis, nasal polyps and their pre- and post-surgery, chronic rhinitis, etc. Glucocorticoid has obvious anti-inflammatory, anti-allergic and edema reducing effects, and has the effect of promoting the gradual recovery of the diseased nasal mucosa to normal. However, many patients have concerns about the application of glucocorticosteroids in clinical practice, thinking that glucocorticosteroids have large side effects and are easy to gain weight, so they are not willing to accept glucocorticosteroid treatment. In fact, most of the knowledge about hormones that patients know or understand may be based on the application of systemic glucocorticoids (injection or oral administration), while intranasal spray hormone drugs are local drugs, and their doses are very small compared with systemic drugs, and they mainly work locally, and very few drugs are really utilized systemically, and some nasal glucocorticoids are less than 0.1% utilized systemically. Therefore, intranasal glucocorticoid sprays have basically no significant effect on the systemic system. Of course, it does not mean that intranasal spray hormones do not have any side effects. A few patients may experience local adverse effects such as nasal dryness and nasal bleeding, and very few patients are at risk of septal perforation after long-term use of nasal hormones. In this regard, the former can apply some nasal oils to reduce or alleviate the side effects, while the latter is mostly related to incorrect nasal spraying methods. 3. Principles of intranasal spray hormone application Firstly, the correct nasal spraying method should be mastered. When spraying medicine, generally use the left hand to spray the right nose and the right hand to spray the left nose, so that the medicine can better enter the deep part of the nasal cavity to better play the effect of the medicine, and can largely avoid the risk of septal perforation due to long-term spraying in the middle direction of the nasal cavity. Secondly, the number of times the drug is used, generally speaking, the initial use of once a day, each side of the nostril spray 2 snap, but also once in the morning and once in the evening, each side of the nostril spray 1 snap. According to the degree of change of lesions and symptoms to adjust the number of medication, lesions and symptoms gradually reduced or alleviated can reduce the number of medication, such as changing to every other day, a spray, 2 times a week. Third, in terms of medication time, generally speaking, allergic rhinitis and nasal polyps should be applied continuously for 3 to 6 months after surgery, and chronic rhinitis for 1 to 3 months.