Gout attacks are painful, while remission periods can be asymptomatic, and are often seen as a rich disease or minor ailment. So is gout really just a minor ailment? Typically, gout is a metabolic disease that occurs in middle-aged and older men and postmenopausal women. In recent years, gout has shown a younger trend, and you can often see gout patients in their 20s accompanied by their parents in the clinic. Gout is often associated with increased uric acid, hyperuricemia, episodes of acute and chronic arthritis, and deposits of uric acid crystals in the joints (gout stones) and kidneys. Gout usually starts with the involvement of only one joint, commonly the first metatarsophalangeal joint, tarsal joint, ankle joint, and knee joint. The first acute gout attack often occurs at night with severe joint pain and swelling. The joint rapidly becomes red, swollen, and painful to the touch. Early attacks usually resolve on their own within 3 to 10 days, and most patients do not have any residual symptoms until they have another attack. Long-term recurrent gout attacks can cause bone erosion and defects in the joint and fibrosis of the surrounding tissues, resulting in stiffness and limited movement of the joint, and can break down to form fistulas. In addition, urate crystals can be deposited in several parts of the joint, tendon sheaths, and connective tissue of the skin, forming yellowish-white, bulging masses of varying sizes known as gout stones. In untreated patients, gouty stones develop in 70% of patients 20 years after the first symptoms. About 1/3 of patients with chronic gout have kidney damage, manifested as urinary stones, chronic gouty nephropathy, or even acute renal failure. Therefore, patients with gout must receive standardized treatment in specialized departments of regular hospitals. Patients with acute attacks should rest in bed, elevate the affected limbs, and generally should rest until the joint pain is relieved for 72 hours before resuming activities. For gout patients, dietary management is important. High purine foods such as animal offal, bone marrow, seafood, shellfish and crabs should be avoided; fish and shrimp, meat, peas and spinach also contain a certain amount of purines; vegetables, fruits, milk and eggs contain less purines. Young people are advised to drink less sugary drinks. Strictly abstain from alcohol, especially beer, yellow wine and strong alcohol. It has been found that moderate consumption of red wine, yogurt, milk, and eating Yin peaches can reduce blood uric acid. Obesity mitigation must reduce caloric intake while lowering body weight and drinking more water to facilitate uric acid excretion. Strict dietary control can reduce blood uric acid by 60-120 umol/L. Most patients require additional uric acid-lowering medications. Commonly used uric acid-lowering drugs include those that reduce uric acid production and increase uric acid excretion. 1.Benbromarone: a powerful diuretic drug. When taking the drug, we should pay attention to drinking more water and taking sodium bicarbonate to alkalize the urine to facilitate the excretion of uric acid. 2. Allopurinol: It reduces the blood uric acid level by inhibiting the synthesis of uric acid. However, it should be noted that occasionally exfoliative necrotizing dermatitis occurs, the condition is serious and requires rescue treatment. 3.Febuxostat: It is the latest drug to reduce blood uric acid level by inhibiting uric acid synthesis. Two large studies have confirmed that it has a faster onset of action, stable uric acid levels, and fewer hepatic and renal side effects compared to allopurinol. In summary, if not treated properly, gout can be very dangerous, causing not only joint erosion and physical disability, but also serious complications such as kidney failure. However, paying attention to lifestyle and reasonable use of medication, gout is completely preventable and treatable. We hope that gout patients can get rid of the pain of hyperuricemia and gout as soon as possible and resume normal work and life.