The clinical manifestations of lung cancer are closely related to the size, type, development stage, location of tumor and the presence of complications or metastases. They are divided into symptoms and signs caused by primary tumor, symptoms and signs caused by local extension of tumor, symptoms and signs caused by distant metastasis of tumor, and extra-thoracic manifestations of lung cancer, as follows: 1. Symptoms caused by primary tumor mainly include cough, sputum and blood, hemoptysis, shortness of breath, wheezing, chest pain, fever, wasting, etc. 2. Symptoms caused by local extension of tumor mainly include chest pain, hoarseness, dysphagia, pleural effusion, pericardial effusion, superior vena cava obstruction syndrome, Horner syndrome, etc. 3.Symptoms and signs caused by distant metastasis of tumor, including central nervous system metastasis, that is, brain metastasis, which may cause symptoms of increased intracranial pressure such as headache, nausea, vomiting, etc. It may also manifest as vertigo, ataxia, diplopia, personality change, seizure or weakness or even paralysis of one limb. Supraclavicular lymph nodes are the common metastatic sites of lymph node metastasis. The extrathoracic manifestations of lung cancer include endocrine syndrome, connective tissue disease, hematological abnormalities and other manifestations. Therefore, the symptoms of bone metastasis of lung cancer are local pain and pressure pain.