There is a risk of amniotic fluid embolism with a smooth first pregnancy and a second pregnancy, but the probability of it happening is relatively low. Amniotic fluid embolism is a serious complication that occurs during labor and delivery, and is life threatening because amniotic fluid enters the mother’s peripheral circulation through open blood vessels during delivery. The risk of amniotic fluid embolism can occur in a second pregnancy after a successful first birth, only the chances of the risk are lower. Amniotic fluid embolism is triggered by the presence of excess amniotic fluid during pregnancy, which increases the pressure in the amniotic cavity and compresses the amniotic fluid into the mother’s peripheral circulation. During cesarean section and normal delivery, the blood vessels of the local uterine incision open during rupture of membranes, and amniotic fluid easily enters the peripheral circulation, causing amniotic fluid embolism. In pregnant women with placental abruption, amniotic fluid may enter the peripheral circulation through the localized placental abruption surface, which may lead to amniotic fluid embolism. During pregnancy, it is important to do a good job of obstetric examination, timely detection of abnormalities in time to go to the hospital for treatment.