Patients with pancreatitis are often complicated by pleural effusion in the clinic. This condition is due to impaired liver function when the pancreas is heavy, and the ability of liver function to synthesize albumin is reduced, resulting in hypoproteinemia, which can lead to obvious bilateral pleural effusion. If you can actively treat pancreatitis while giving albumin to increase the osmotic pressure in the plasma, the fluid in the pleural cavity will gradually absorb or even disappear. In severe pancreatitis, the complication of systemic multi-organ failure, including pulmonary failure, may also cause pleural effusion. In the case of pleural effusion caused by pancreatitis, it is necessary to find the correct cause for symptomatic treatment, and if necessary, puncture and drainage of pleural effusion can also be performed. Routine physical and chemical index testing of pleural effusion should be performed to further find the main cause of pleural effusion and take appropriate symptomatic supportive treatment measures.