There are individual differences in how long a person can live after a heart transplant, mainly related to the patient’s physical condition prior to the heart transplant, and the rejection reaction after a successful transplant. Clinically, heart transplantation is a mature technique, and if the patient is in good general health prior to surgery, the success rate of transplantation can be 80-90%. The one-year survival rate after heart transplantation can be more than 90%, and the five-year survival rate is more than 80%. When rejection occurs in heart transplantation, if controlled in time, patients can survive for more than 10 years, and long-term survival is generally achieved. With heart transplantation, patients can regain normal heart function and return to normal work, school and life. However, life expectancy can also be affected if patients have rejection reactions after heart transplantation, or if they have other diseases, such as coronary heart disease, cerebrovascular disease, tumors and other problems. Patients after heart transplantation should follow up with the hospital on time, take oral rejection medication on time, and develop good living and eating habits, quit smoking and drinking, and can do appropriate sports to keep a happy mood.