(A) Indications 1, end-stage heart failure with or without ventricular arrhythmias, which cannot be cured by systematic and perfect medical treatment or conventional surgery, with a predicted life expectancy of 1 year. 2.No irreversible damage to other organs (liver, kidney, lung, etc.). 3.Patients and their families can understand and actively cooperate with the transplantation treatment. 4. Common conditions suitable for heart transplantation: (1) advanced primary cardiomyopathy, including dilated, hypertrophic and restrictive cardiomyopathy, and chronic Creutzfeldt-Jakob disease; (2) severe coronary artery disease that cannot be treated with bypass surgery or laser myocardial perforation; (3) complex congenital heart disease that cannot be treated with corrective surgery, such as left ventricular dysplasia; (4) end-stage multivalvular disease that cannot be treated with valve replacement surgery (5) other cardiac trauma and cardiac tumors that are difficult to treat surgically; (6) extensive coronary arteriosclerosis and myocardial fibrosis in the transplanted heart after heart transplantation, etc. (2) Contraindications 1, absolute contraindications (1) active infectious lesions throughout the body. (2) Recent extracardiac malignant tumor. (3) Irreversible failure of lung, liver and kidney. (4) Severe systemic disorders (e.g., systemic connective tissue disease) with limited survival time. (5) Inconsistent ABO blood type between the donor and recipient. (6) Mean pulmonary artery pressure of 8.0 Kpa (60 mmHg) and pulmonary vascular resistance (PVR8Wood units) measured after perfect medical treatment. (7) Serum HIV-positive person. (8) Those who do not comply with treatment or abuse drugs or alcoholism. (9) Psychiatric and psychologically unhealthy individuals. (10) Recent history of severe pulmonary infarction. 2. Relative contraindications (1) Age 65 years. (2)Old pulmonary infarction. (3)Combined diabetes mellitus. (4) Cerebrovascular and peripheral vascular lesions. (5) Chronic hepatitis. (6) Peptic ulcer disease, diverticulitis. (7) Active myocarditis giant cell myocarditis. (8) Cardiac cachexia (e.g., poor body composition, anemia, low egg leukemia, wasting, etc.).